VEGF-C Antibody (E-6): sc-374628

VEGF-C Antibody (E-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects VEGF-C protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-VEGF-C antibody (E-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. VEGF-C plays a crucial role in lymphangiogenesis, the formation of lymphatic vessels, which is essential for maintaining fluid homeostasis and immune responses in tissues. By promoting lymphatic endothelial cell growth, VEGF-C contributes to tissue repair and immune surveillance, while also being involved in cancer metastasis and lymphedema. VEGF-C binding and activation of Flt-4 and Flk-1 receptors highlights VEGF-C′s importance in both normal and disease states, making VEGF-C an important target for therapeutic interventions aimed at modulating angiogenesis and lymphangiogenesis.

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VEGF-C Antibody (E-6) References:

1. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.  |  Plate, KH., et al. 1992. Nature. 359: 845-8. PMID: 1279432
2. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation.  |  Breier, G., et al. 1992. Development. 114: 521-32. PMID: 1592003
3. The vascular endothelial growth factor family of polypeptides.  |  Ferrara, N., et al. 1991. J Cell Biochem. 47: 211-8. PMID: 1791185
4. VEGF-C differentially regulates VEGF-A expression in ocular and cancer cells; promotes angiogenesis via RhoA mediated pathway.  |  Kumar, B., et al. 2011. Angiogenesis. 14: 371-80. PMID: 21698469
5. Induction of angiogenesis during the transition from hyperplasia to neoplasia.  |  Folkman, J., et al. 1989. Nature. 339: 58-61. PMID: 2469964
6. VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption.  |  Nurmi, H., et al. 2015. EMBO Mol Med. 7: 1418-25. PMID: 26459520
7. Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation.  |  Schwager, S., et al. 2018. JCI Insight. 3: PMID: 30518687
8. VEGF-C and Mortality in Patients With Suspected or Known Coronary Artery Disease.  |  Wada, H., et al. 2018. J Am Heart Assoc. 7: e010355. PMID: 30554564
9. Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune cells infiltration in endometriosis.  |  Li, WN., et al. 2020. Proc Natl Acad Sci U S A. 117: 25859-25868. PMID: 33004630
10. Arterial Delivery of VEGF-C Stabilizes Atherosclerotic Lesions.  |  Silvestre-Roig, C., et al. 2021. Circ Res. 128: 284-286. PMID: 33210556
11. VEGF-C mediates tumor growth and metastasis through promoting EMT-epithelial breast cancer cell crosstalk.  |  Kong, D., et al. 2021. Oncogene. 40: 964-979. PMID: 33299122
12. Simvastatin alleviates glymphatic system damage via the VEGF-C/VEGFR3/PI3K-Akt pathway after experimental intracerebral hemorrhage.  |  Liao, J., et al. 2024. Brain Res Bull. 216: 111045. PMID: 39097032

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VEGF-C Antibody (E-6) has 29 citations in a variety of scientific publications.

Primary antibodies like Anti-VEGF-C Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VEGF-C Antibody (E-6) Specifications

Alternate Product Name: VEGF-C

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 103-137

Epitope Target: VEGF-C

Epitope Species: human

Product Reactivity/Detection: precursor and mature VEGF-C

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 29 citations in various scientific publications

Available Conjugates/Forms for VEGF-C Antibody (E-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin