VEGF-B Antibody (56-1): sc-81670

VEGF-B Antibody (56-1) is a mouse monoclonal IgG1 antibody that detects VEGF-B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). VEGF-B plays a crucial role in angiogenesis, which is the formation of new blood vessels from pre-existing ones, a process that is vital for normal physiological functions as well as for tumor growth and metastasis. VEGF-B is predominantly expressed in heart and skeletal muscle, where VEGF-B promotes endothelial cell survival and migration, thereby facilitating blood vessel formation. Notably, VEGF-B exists in two isoforms, VEGF-B167 and VEGF-B186, which are generated through alternative splicing and may have distinct biological activities. The interaction of VEGF-B with its receptors, particularly Flt-1, is essential for mediating angiogenic effects, making VEGF-B a significant target for therapeutic interventions in diseases characterized by abnormal blood vessel growth, such as cancer. The genes encoding human VEGF-B are located on chromosome 11q13, highlighting genetic significance in vascular biology and pathology. Anti-VEGF-B antibody (56-1) serves as an invaluable tool for researchers investigating mechanisms of angiogenesis and implications in various diseases.

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VEGF-B Antibody (56-1) References:

1. Novel function of VEGF-B as an antioxidant and therapeutic implications.  |  Chen, R., et al. 2019. Pharmacol Res. 143: 33-39. PMID: 30851357
2. VEGF-B antibody and interleukin-22 fusion protein ameliorates diabetic nephropathy through inhibiting lipid accumulation and inflammatory responses.  |  Shen, Y., et al. 2021. Acta Pharm Sin B. 11: 127-142. PMID: 33532185
3. VEGF-A/VEGF-B/VEGF-C expressions in non-hereditary, non-metastatic phaeochromocytoma.  |  Abe, I., et al. 2021. Histol Histopathol. 36: 645-652. PMID: 33734425
4. Resveratrol Treats UVB-Induced Photoaging by Anti-MMP Expression, through Anti-Inflammatory, Antioxidant, and Antiapoptotic Properties, and Treats Photoaging by Upregulating VEGF-B Expression.  |  Cui, B., et al. 2022. Oxid Med Cell Longev. 2022: 6037303. PMID: 35028009
5. Inhibition of VEGF-B signaling prevents non-alcoholic fatty liver disease development by targeting lipolysis in the white adipose tissue.  |  Falkevall, A., et al. 2023. J Hepatol. 78: 901-913. PMID: 36717026
6. VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats.  |  Samuelsson, AM., et al. 2023. Cardiovasc Res. 119: 1553-1567. PMID: 36951047
7. Melatonin attenuates diabetic cardiomyopathy by increasing autophagy of cardiomyocytes via regulation of VEGF-B/GRP78/PERK signaling pathway.  |  Zhang, S., et al. 2024. Cardiovasc Diabetol. 23: 19. PMID: 38195474
8. Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy.  |  Sultan, I., et al. 2024. Circ Res. 134: 1465-1482. PMID: 38655691
9. Autocrine VEGF-B signaling maintains lipid synthesis and mitochondrial fitness to support T cell immune responses.  |  He, J., et al. 2024. J Clin Invest. 134: PMID: 39145452
10. VEGF-B prevents chronic hyperglycemia-induced retinal vascular leakage by regulating the CDC42-ZO1/VE-cadherin pathway.  |  Xu, Y., et al. 2024. FASEB J. 38: e70019. PMID: 39215561

The preferred VEGF-B antibody is VEGF-B Antibody (RM0008-6E72): sc-101582.