VEGF-B Antibody (RM0008-6E72): sc-101582

VEGF-B Antibody (RM0008-6E72) is a rat monoclonal IgG2 antibody that detects VEGF-B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-VEGF-B antibody (RM0008-6E72) is available as a non-conjugated format for studying VEGF-B′s role in various biological processes. VEGF-B plays a significant role in angiogenesis, forming new blood vessels, which is critical in both normal physiological conditions and pathological states such as cancer. VEGF-B (RM0008-6E72) antibody targets proteins primarily located in the extracellular space, where VEGF-B interacts with endothelial cells to promote proliferation and migration, facilitating new blood vessel development. This interaction becomes particularly important during tumorigenesis, as angiogenesis can enhance tumor growth and metastasis. VEGF-B exists in two isoforms, VEGF-B167 and VEGF-B186, which are differentially expressed in various tissues, including heart and skeletal muscle, and often co-express with other vascular endothelial growth factor family members. Understanding VEGF-B localization and function remains essential for elucidating roles in both health and disease, making VEGF-B (RM0008-6E72) monoclonal antibody a valuable research tool for investigating angiogenic processes.

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VEGF-B Antibody (RM0008-6E72) References:

1. VEGF-A and VEGF-B mRNA expression in gastro-oesophageal cancers.  |  Angelescu, C., et al. 2013. Clin Transl Oncol. 15: 313-20. PMID: 22872519
2. VEGF-B expression in colorectal carcinomas and its relevance for tumor progression.  |  Jayasinghe, C., et al. 2013. Histol Histopathol. 28: 647-53. PMID: 23417498
3. VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart.  |  Kivelä, R., et al. 2014. EMBO Mol Med. 6: 307-21. PMID: 24448490
4. VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients.  |  Yang, X., et al. 2015. Proc Natl Acad Sci U S A. 112: E2900-9. PMID: 25991856
5. Insights into the Mechanisms Involved in Protective Effects of VEGF-B in Dopaminergic Neurons.  |  Caballero, B., et al. 2017. Parkinsons Dis. 2017: 4263795. PMID: 28473940
6. VEGF-B Levels in the Vitreous of Diabetic and Non-Diabetic Patients with Ocular Diseases and Its Correlation with Structural Parameters.  |  Mesquita, J., et al. 2017. Med Sci (Basel). 5: PMID: 29099033
7. Changes in the Expression Profile of VEGF-A, VEGF-B, VEGFR-1, VEGFR-2 in Different Grades of Endometrial Cancer.  |  Dziobek, K., et al. 2019. Curr Pharm Biotechnol. 20: 955-963. PMID: 31322068
8. miR-345-5p regulates adipogenesis via targeting VEGF-B.  |  Liu, X., et al. 2020. Aging (Albany NY). 12: 17114-17121. PMID: 32927430
9. Clinical efficacy and changes of serum VEGF-A, VEGF-B, and PLGF after conbercept treating neovascular age-related macular degeneration.  |  Chen, XD., et al. 2023. Int J Ophthalmol. 16: 1489-1495. PMID: 37724264
10. VEGF-B is involved in diabetic peripheral neuropathy in patients with type 2 diabetes.  |  Zhou, R., et al. 2024. Growth Factors. 42: 101-110. PMID: 39001597

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-VEGF-B Antibody (RM0008-6E72) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-VEGF-B Antibody (RM0008-6E72) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

VEGF-B Antibody (RM0008-6E72) Specifications

Alternate Product Name: VEGF-B

Product Clone Name: RM0008-6E72

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₂

Amino Acids:

Epitope Target: VEGF-B186

Epitope Species: mouse

Product Reactivity/Detection: VEGF-B186

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG₂ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for VEGF-B Antibody (RM0008-6E72): N/A