VEGF Antibody (VG76e): sc-53463

VEGF Antibody (VG76e) is a mouse monoclonal IgG1 kappa light chain antibody that detects VEGF protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-VEGF antibody (VG76e) plays a crucial role in the study of angiogenesis, a process that is vital for both normal physiological functions and pathological conditions such as cancer. VEGF (VG76e) antibody targets VEGF protein primarily located in the extracellular space, where VEGF is secreted by various cell types, including tumor cells, and is essential for the formation of new blood vessels. This localization is significant because VEGF interacts with endothelial cells, promoting their proliferation and migration, which are critical steps in angiogenesis. VEGF′s ability to stimulate blood vessel formation is particularly important in the context of tumor growth and metastasis, as tumors require a robust blood supply to sustain their growth and spread. Additionally, VEGF presence in the tumor microenvironment can influence the behavior of surrounding cells, further contributing to tumor progression. Understanding VEGF dynamics and interactions within the cellular environment can provide valuable insights into therapeutic strategies aimed at inhibiting angiogenesis in cancer treatment.

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VEGF Antibody (VG76e) References:

1. Targeting VEGF-A to treat cancer and age-related macular degeneration.  |  Ferrara, N., et al. 2007. Annu Rev Med. 58: 491-504. PMID: 17052163
2. VEGF as an inhibitor of tumor vessel maturation: implications for cancer therapy.  |  Greenberg, JI. and Cheresh, DA. 2009. Expert Opin Biol Ther. 9: 1347-56. PMID: 19761418
3. [VEGF and central nervous system diseases].  |  Zhang, LY., et al. 2009. Zhejiang Da Xue Xue Bao Yi Xue Ban. 38: 644-8. PMID: 20014493
4. Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review.  |  Yang, S., et al. 2016. Drug Des Devel Ther. 10: 1857-67. PMID: 27330279
5. Stabilization of VEGF i-motif structure by CpG methylation.  |  Kimura, K., et al. 2022. Biochem Biophys Res Commun. 594: 88-92. PMID: 35078112
6. Overexpression of VEGF in the MOPC 315 Plasmacytoma Induces Tumor Immunity in Mice.  |  Kim, BG., et al. 2022. Int J Mol Sci. 23: PMID: 35563626
7. Neuroprotective Effects of VEGF in the Enteric Nervous System.  |  Hecking, I., et al. 2022. Int J Mol Sci. 23: PMID: 35743202
8. Robust coupling of angiogenesis and osteogenesis by VEGF-decorated matrices for bone regeneration.  |  Burger, MG., et al. 2022. Acta Biomater. 149: 111-125. PMID: 35835287
9. VEGF overexpressed mesoangioblasts enhance urethral and vaginal recovery following simulated vaginal birth in rats.  |  Mori da Cunha, MGMC., et al. 2023. Sci Rep. 13: 8622. PMID: 37244975
10. [Lysinuric protein intolerance--two patients in a family with loss of consciousness and growth retardation].  |  Yoshimura, T., et al. 1983. Rinsho Shinkeigaku. 23: 140-6. PMID: 6407796

The preferred VEGF antibody is VEGF Antibody (C-1): sc-7269.