VCP Antibody (G-8): sc-374055
- VCP Antibody (G-8) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 760-797 near the C-terminus of VCP of human origin
- recommended for detection of VCP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for VCP Antibody (G-8) for WB and IHC(P) applications. This reagent is now offered in a bundle with VCP Antibody (G-8) (see ordering information below).
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VCP Antibody (G-8) is a mouse monoclonal IgG2b antibody that detects valosin containing protein (VCP) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). VCP plays a crucial role in cellular processes, particularly in the regulation of the cell cycle and membrane functions, by facilitating the extraction of misfolded proteins from the endoplasmic reticulum and promoting their degradation. This function is vital for maintaining cellular homeostasis and preventing the accumulation of damaged proteins, which can lead to various diseases, including neurodegenerative disorders. VCP′s interaction with ubiquitinated proteins, such as IκB-α, and association with the 26S proteasome highlight VCP′s importance in the ubiquitin-proteasome pathway, a key mechanism for protein turnover and quality control within the cell. Anti-VCP antibody (G-8) is an essential tool for researchers studying these critical cellular processes and their implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
VCP Antibody (G-8) References:
- Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. | Ju, JS., et al. 2009. J Cell Biol. 187: 875-88. PMID: 20008565
- Valosin-containing protein (VCP) in novel feedback machinery between abnormal protein accumulation and transcriptional suppression. | Koike, M., et al. 2010. J Biol Chem. 285: 21736-49. PMID: 20410307
- Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3. | Laço, MN., et al. 2012. PLoS One. 7: e43563. PMID: 22970133
- Valosin-containing protein (VCP/p97)-expression correlates with prognosis of HPV- negative oropharyngeal squamous cell carcinoma (OSCC). | Meyer, MF., et al. 2014. PLoS One. 9: e114170. PMID: 25463965
- The valosin-containing protein is a novel repressor of cardiomyocyte hypertrophy induced by pressure overload. | Zhou, N., et al. 2017. Aging Cell. 16: 1168-1179. PMID: 28799247
- Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron. | Chua, NK., et al. 2019. Biochem J. 476: 2545-2560. PMID: 31471528
- Measurement of ATPase Activity of Valosin-containing Protein/p97. | Suvarna, K., et al. 2020. Bio Protoc. 10: e3516. PMID: 33654741
- Targeting VCP potentiates immune checkpoint therapy for colorectal cancer. | Wang, F., et al. 2023. Cell Rep. 42: 113318. PMID: 37865914
- TNF-α-Induced KAT2A Impedes BMMSC Quiescence by Mediating Succinylation of the Mitophagy-Related Protein VCP. | Su, Z., et al. 2024. Adv Sci (Weinh). 11: e2303388. PMID: 38145956
- ATPase Valosin-Containing Protein (VCP) Is Involved During the Replication and Egress of Sialodacryoadenitis Virus (SDAV) in Neurons. | Bartak, M., et al. 2024. Int J Mol Sci. 25: PMID: 39519185
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VCP Antibody (G-8) | sc-374055 | 200 µg/ml | $322.00 | |||
VCP Antibody (G-8): m-IgG Fc BP-HRP Bundle | sc-540418 | 200 µg Ab; 10 µg BP | $361.00 | |||
VCP (G-8) Neutralizing Peptide | sc-374055 P | 100 µg/0.5 ml | $69.00 |