VCAM-1 Antibody (1G11): sc-18854
- VCAM-1 Antibody (1G11) is a mouse monoclonal IgG1 κ, cited in 13 publications, provided at 200 µg/ml
- raised against a full length human protein
- recommended for detection of VCAM-1 of human origin by WB, IP, IF, FCM and ELISA
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for inhibiting T lymphocyte adhesion to TNF-stimulated endothelial cells, sc-18854 L, 200 µg/0.1 ml
- See VCAM-1 (E-10): sc-13160 for VCAM-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for VCAM-1 Antibody (1G11) for WB applications. These reagents are now offered in bundles with VCAM-1 Antibody (1G11) (see ordering information below).
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VCAM-1 Antibody (1G11) is a mouse monoclonal IgG1 kappa light chain antibody raised against the full-length human Vascular Cell Adhesion Molecule 1 (VCAM-1), also known as CD106. VCAM-1 is a transmembrane glycoprotein predominantly expressed on the surface of activated endothelial cells. Cellular localization on the membrane is crucial as VCAM-1 mediates leukocyte adhesion to the endothelium, facilitating transmigration during immune responses and inflammation. This cell-surface positioning allows VCAM-1 to interact directly with integrins like VLA-4 (α4β1) on leukocytes, playing a significant role in immune surveillance and inflammatory disease pathogenesis. Pro-inflammatory stimuli such as interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), and lipopolysaccharide (LPS) upregulate VCAM-1 expression, linking VCAM-1 to conditions like atherosclerosis, rheumatoid arthritis, and other vascular inflammatory disorders. Anti-VCAM-1 antibody (1G11) aids in studying endothelial activation, leukocyte adhesion, and mechanisms underlying vascular inflammation. VCAM-1 (1G11) antibody reacts with human VCAM-1 and is suitable for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Understanding VCAM-1 cellular localization and function is essential for developing therapeutic strategies against diseases involving abnormal leukocyte trafficking and endothelial dysfunction.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VCAM-1 Antibody (1G11) | sc-18854 | 200 µg/ml | $322.00 | |||
VCAM-1 Antibody (1G11): m-IgG Fc BP-HRP Bundle | sc-536601 | 200 µg Ab; 10 µg BP | $361.00 | |||
VCAM-1 Antibody (1G11): m-IgGκ BP-HRP Bundle | sc-533756 | 200 µg Ab; 40 µg BP | $361.00 | |||
VCAM-1 Antibody (1G11): m-IgG1 BP-HRP Bundle | sc-544699 | 200 µg Ab; 20 µg BP | $361.00 | |||
VCAM-1 Antibody (1G11) FITC | sc-18854 FITC | 200 µg/ml | $336.00 | |||
VCAM-1 Antibody (1G11) L | sc-18854 L | 200 µg/0.1 ml | $322.00 | |||
VCAM-1 Antibody (1G11) PE | sc-18854 PE | 200 µg/ml | $349.00 |