Vangl1 Antibody (E-3): sc-166844
- Vangl1 Antibody (E-3) is a mouse monoclonal IgG1 κ Vangl1 antibody, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 281-298 within a cytoplasmic domain of Vangl1 of human origin
- Vangl1 Antibody (E-3) is recommended for detection of Vangl1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-Vangl1 Antibody (E-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Vangl1 Antibody (E-3) for WB applications. These reagents are now offered in bundles with Vangl1 Antibody (E-3) (see ordering information below).
QUICK LINKS
Vangl1 Antibody (E-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects Vangl1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Vangl1 antibody (E-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Vangl1, also known as Van Gogh-like protein 1, plays a crucial role in establishing planar cell polarity (PCP) during embryonic development, which is essential for proper tissue organization and function. Vangl1 is primarily localized to the cell membrane, where Vangl1 interacts with other proteins involved in signaling pathways that regulate cell orientation and movement. Proper functioning of Vangl1 is vital, as disruptions in Vangl1 activity can lead to developmental defects and have been implicated in various cancers, including gastric and pancreatic tumors. The gene encoding Vangl1 is located on human chromosome 1p11-p13.1, and Vangl1 expression is notably high in reproductive tissues, highlighting a potential role in developmental processes. anti-Vangl1 antibody (E-3) is an invaluable tool for researchers studying the mechanisms of cell polarity and implications in cancer biology and developmental disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Vangl1 Antibody (E-3) References:
- Identification and developmental expression pattern of van gogh-like 1, a second zebrafish strabismus homologue. | Jessen, JR. and Solnica-Krezel, L. 2004. Gene Expr Patterns. 4: 339-44. PMID: 15053985
- PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. | Lu, X., et al. 2004. Nature. 430: 93-8. PMID: 15229603
- Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. | Torban, E., et al. 2004. J Biol Chem. 279: 52703-13. PMID: 15456783
- Van Gogh-like2 (Strabismus) and its role in planar cell polarity and convergent extension in vertebrates. | Torban, E., et al. 2004. Trends Genet. 20: 570-7. PMID: 15475117
- Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. | Phillips, HM., et al. 2005. Circ Res. 96: 292-9. PMID: 15637299
- Identification and characterization of rat Ankrd6 gene in silico. | Katoh, M. and Katoh, M. 2005. Int J Mol Med. 15: 359-63. PMID: 15647854
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vangl1 Antibody (E-3) | sc-166844 | 200 µg/ml | $322.00 | |||
Vangl1 Antibody (E-3): m-IgG Fc BP-HRP Bundle | sc-529067 | 200 µg Ab; 10 µg BP | $361.00 | |||
Vangl1 Antibody (E-3): m-IgGκ BP-HRP Bundle | sc-521768 | 200 µg Ab, 40 µg BP | $361.00 | |||
Vangl1 Antibody (E-3): m-IgG1 BP-HRP Bundle | sc-543300 | 200 µg Ab; 20 µg BP | $361.00 | |||
Vangl1 Antibody (E-3) AC | sc-166844 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Vangl1 Antibody (E-3) HRP | sc-166844 HRP | 200 µg/ml | $322.00 | |||
Vangl1 Antibody (E-3) FITC | sc-166844 FITC | 200 µg/ml | $336.00 | |||
Vangl1 Antibody (E-3) PE | sc-166844 PE | 200 µg/ml | $349.00 | |||
Vangl1 Antibody (E-3) Alexa Fluor® 488 | sc-166844 AF488 | 200 µg/ml | $364.00 | |||
Vangl1 Antibody (E-3) Alexa Fluor® 546 | sc-166844 AF546 | 200 µg/ml | $364.00 | |||
Vangl1 Antibody (E-3) Alexa Fluor® 594 | sc-166844 AF594 | 200 µg/ml | $364.00 | |||
Vangl1 Antibody (E-3) Alexa Fluor® 647 | sc-166844 AF647 | 200 µg/ml | $364.00 | |||
Vangl1 Antibody (E-3) Alexa Fluor® 680 | sc-166844 AF680 | 200 µg/ml | $364.00 | |||
Vangl1 Antibody (E-3) Alexa Fluor® 790 | sc-166844 AF790 | 200 µg/ml | $364.00 | |||
Vangl1 (E-3) Neutralizing Peptide | sc-166844 P | 100 µg/0.5 ml | $69.00 |