V-ATPase C1 Antibody (H-5): sc-166848

V-ATPase C1 Antibody (H-5) is a mouse monoclonal IgG1 antibody that detects V-ATPase C in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). V-ATPase C is an essential auxiliary subunit of the vacuolar-type H+-ATPase complex, which plays a critical role in the acidification of eukaryotic intracellular organelles, a process vital for numerous cellular functions such as protein sorting, nutrient storage, and cellular signaling. V-ATPase C contributes to the stability and activity of the enzyme, making this subunit crucial for proper assembly and function of the V-ATPase complex. V-ATPase C shows ubiquitous expression across various tissues, indicating a fundamental role in maintaining cellular homeostasis. The gene encoding human V-ATPase C is located on chromosome 8q22.3, and V-ATPase C interaction with other subunits, such as V-ATPase D, is essential for the overall functionality of the V-ATPase complex. Anti-V-ATPase C antibody (H-5) enables researchers to gain insights into the dynamics of proton transport and the physiological implications of V-ATPase activity in health and disease.

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V-ATPase C1 Antibody (H-5) References:

1. Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa.  |  García-García, A., et al. 2012. Biotech Histochem. 87: 133-9. PMID: 21526910
2. Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis.  |  Feng, S., et al. 2013. Int J Biol Sci. 9: 853-62. PMID: 24155661
3. Atp6v1c1 may regulate filament actin arrangement in breast cancer cells.  |  Cai, M., et al. 2014. PLoS One. 9: e84833. PMID: 24454753
4. Expression of ATP6V1C1 during oral carcinogenesis.  |  Oliveira Alves, MG., et al. 2016. Biotech Histochem. 91: 263-8. PMID: 26984774
5. Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity.  |  McConnell, M., et al. 2017. Oncotarget. 8: 47675-47690. PMID: 28504970
6. MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H⁺ Transporting V1 Subunit C1.  |  Jing, F., et al. 2019. Int J Mol Sci. 20: PMID: 30781750
7. Bafilomycin-A1 and ML9 Exert Different Lysosomal Actions to Induce Cell Death.  |  Shaikh, S., et al. 2019. Curr Mol Pharmacol. 12: 261-271. PMID: 30854984
8. The ATPase subunit of ATP6V1C1 inhibits autophagy and enhances radiotherapy resistance in esophageal squamous cell carcinoma.  |  Yao, X., et al. 2021. Gene. 768: 145261. PMID: 33183740
9. Dominantly acting variants in ATP6V1C1 and ATP6V1B2 cause a multisystem phenotypic spectrum by altering lysosomal and/or autophagosome function.  |  Carpentieri, G., et al. 2024. HGG Adv. 5: 100349. PMID: 39210597
10. ATP6V1C1, associated with the tumor microenvironment and mTORC1 signaling pathway, is a potential diagnostic, prognostic, and therapeutic biomarker for hepatocellular carcinoma.  |  Pan, Y., et al. 2024. Discov Oncol. 15: 673. PMID: 39557733

The preferred V-ATPase C1 antibody is V-ATPase C1 Antibody (G-5): sc-271077.