UTP6 Antibody (E-9): sc-398913
- UTP6 Antibody (E-9) is a mouse monoclonal IgG2b κ UTP6 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 390-411 within an internal region of UTP6 of human origin
- UTP6 Antibody (E-9) is recommended for detection of UTP6 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-UTP6 Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for UTP6 Antibody (E-9) for WB applications. These reagents are now offered in bundles with UTP6 Antibody (E-9) (see ordering information below).
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UTP6 Antibody (E-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects UTP6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-UTP6 antibody (E-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. UTP6, also known as U3 small nucleolar RNA-associated protein 6 homolog, C17orf40, or hepatocellular carcinoma-associated antigen 66, is a 597 amino acid protein that plays a crucial role in the nucleolar processing of pre-18S ribosomal RNA, which is essential for ribosome biogenesis and protein synthesis. UTP6 is localized primarily in the nucleus, where UTP6 participates in the assembly and maturation of ribonucleoprotein complexes. The presence of five half-a-tetratricopeptide (HAT) repeats in UTP6 suggests UTP6′s involvement in RNA metabolism, particularly in pre-rRNA processing, highlighting UTP6′s importance in cellular function and growth. The gene encoding UTP6 is located on human chromosome 17, a region that comprises over 2.5% of the human genome and encodes more than 1,200 genes, underscoring UTP6′s potential significance in various biological processes and relevance in studies related to cancer and other diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
UTP6 Antibody (E-9) References:
- A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions. | Jenne, DE., et al. 2000. Genomics. 66: 93-7. PMID: 10843809
- Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. | Wang, Y., et al. 2002. J Immunol. 169: 1102-9. PMID: 12097419
- Functional characterization of Pwp2, a WD family protein essential for the assembly of the 90 S pre-ribosomal particle. | Dosil, M. and Bustelo, XR. 2004. J Biol Chem. 279: 37385-97. PMID: 15231838
- A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing. | Champion, EA., et al. 2008. Mol Cell Biol. 28: 6547-56. PMID: 18725399
- Expression analysis of genes lying in the NF1 microdeletion interval points to four candidate modifiers for neurofibroma formation. | Bartelt-Kirbach, B., et al. 2009. Neurogenetics. 10: 79-85. PMID: 18850118
- A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics. | Champion, EA., et al. 2009. Protein Eng Des Sel. 22: 431-9. PMID: 19515729
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UTP6 Antibody (E-9) | sc-398913 | 200 µg/ml | $322.00 | |||
UTP6 Antibody (E-9): m-IgG Fc BP-HRP Bundle | sc-530965 | 200 µg Ab; 10 µg BP | $361.00 | |||
UTP6 Antibody (E-9): m-IgGκ BP-HRP Bundle | sc-524532 | 200 µg Ab, 40 µg BP | $361.00 | |||
UTP6 Antibody (E-9): m-IgG2b BP-HRP Bundle | sc-550244 | 200 µg Ab; 10 µg BP | $361.00 | |||
UTP6 Antibody (E-9) AC | sc-398913 AC | 500 µg/ml, 25% agarose | $424.00 | |||
UTP6 Antibody (E-9) HRP | sc-398913 HRP | 200 µg/ml | $322.00 | |||
UTP6 Antibody (E-9) FITC | sc-398913 FITC | 200 µg/ml | $336.00 | |||
UTP6 Antibody (E-9) PE | sc-398913 PE | 200 µg/ml | $349.00 | |||
UTP6 Antibody (E-9) Alexa Fluor® 488 | sc-398913 AF488 | 200 µg/ml | $364.00 | |||
UTP6 Antibody (E-9) Alexa Fluor® 546 | sc-398913 AF546 | 200 µg/ml | $364.00 | |||
UTP6 Antibody (E-9) Alexa Fluor® 594 | sc-398913 AF594 | 200 µg/ml | $364.00 | |||
UTP6 Antibody (E-9) Alexa Fluor® 647 | sc-398913 AF647 | 200 µg/ml | $364.00 | |||
UTP6 Antibody (E-9) Alexa Fluor® 680 | sc-398913 AF680 | 200 µg/ml | $364.00 | |||
UTP6 Antibody (E-9) Alexa Fluor® 790 | sc-398913 AF790 | 200 µg/ml | $364.00 | |||
UTP6 (E-9) Neutralizing Peptide | sc-398913 P | 100 µg/0.5 ml | $69.00 |