USP31 Antibody (4F2): sc-100634

USP31 Antibody (4F2) is a mouse monoclonal IgG2a kappa light chain antibody that detects USP31 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-USP31 antibody (4F2) is available as the non-conjugated monoclonal isotype antibody. USP31, or ubiquitin specific peptidase 31, is a crucial 1,352 amino acid protein belonging to the peptidase C19 family, which plays a significant role in the ubiquitin-proteasome system. USP31 is primarily localized in the nucleus, where USP31 functions as a deubiquitinating enzyme, removing ubiquitin moieties from ubiquitinylated proteins and ubiquitin-fused precursors. This activity protects these proteins from proteasomal degradation, thereby regulating various cellular processes such as signal transduction, transcriptional activation, and cell cycle progression. The regulation of protein stability through deubiquitination is essential for maintaining cellular homeostasis and responding to stress signals. USP31 exists in two isoforms due to alternative splicing, which may contribute to functional diversity in different cellular contexts. With broad tissue expression and critical role in cellular regulation, USP31 serves as a key player in maintaining the balance of protein turnover and function within the cell.

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USP31 Antibody (4F2) References:

1. Human and mouse proteases: a comparative genomic approach.  |  Puente, XS., et al. 2003. Nat Rev Genet. 4: 544-58. PMID: 12838346
2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.  |  Quesada, V., et al. 2004. Biochem Biophys Res Commun. 314: 54-62. PMID: 14715245
3. Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis.  |  Lockhart, PJ., et al. 2004. DNA Seq. 15: 9-14. PMID: 15354349
4. Transcriptome analysis of human gastric cancer.  |  Oh, JH., et al. 2005. Mamm Genome. 16: 942-54. PMID: 16341674

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-USP31 Antibody (4F2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-USP31 Antibody (4F2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

USP31 Antibody (4F2) Specifications

Alternate Product Name: USP31

Product Clone Name: 4F2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1254-1353

Epitope Target: USP31

Epitope Species: human

Product Reactivity/Detection: USP31

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for USP31 Antibody (4F2): N/A