UROS Antibody (G-9): sc-365120
- UROS Antibody (G-9) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-265 representing full length UROS of human origin
- Anti-UROS Antibody (G-9) is recommended for detection of Uroporphyrinogen-III synthase (UROS) of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-UROS Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for UROS Antibody (G-9) for WB applications. This reagent is now offered in a bundle with UROS Antibody (G-9) (see ordering information below).
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SEE ALSO...
UROS Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects Uroporphyrinogen-III synthase (UROS) from mouse, rat, and human sources through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UROS (G-9) antibody is available non-conjugated or conjugated to agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants. Uroporphyrinogen-III synthase (UROS), also known as hydroxymethylbilane hydrolyase, is a 265-amino acid protein catalyzing hydroxymethylbilane conversion to uroporphyrinogen III in heme biosynthesis. UROS functions primarily in skeletal muscle, heart muscle, caudate nucleus, and amygdala, indicating significance in metabolically active tissues. UROS acts as a monomer essential for porphyrin biosynthesis through the Shemin pathway, where gene defects can cause autosomal recessive Gunther disease or congenital erythropoietic porphyria (CEP), characterized by uroporphyrin I accumulation in bone marrow, peripheral blood, and organs, often leading to severe complications and early mortality.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
UROS Antibody (G-9) References:
- Lentivirus-mediated gene transfer of uroporphyrinogen III synthase fully corrects the porphyric phenotype in human cells. | Géronimi, F., et al. 2003. J Mol Med (Berl). 81: 310-20. PMID: 12721665
- HLA-DQA1 and polymarker in the Uros population from Peruvian Highland. | Torres, G., et al. 2003. J Forensic Sci. 48: 1426-7. PMID: 14640297
- Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia coli. | Omata, Y., et al. 2004. J Biochem. 136: 211-20. PMID: 15496592
- Overrepresentation of the founder PPOX gene mutation R59W in a South African patient with severe clinical manifestation of porphyria. | de Villiers, JN., et al. 2005. Exp Dermatol. 14: 50-5. PMID: 15660919
- Successful match-unrelated donor bone marrow transplantation for congenital erythropoietic porphyria (Günther disease). | Dupuis-Girod, S., et al. 2005. Eur J Pediatr. 164: 104-7. PMID: 15703981
- Regional assignment of the human uroporphyrinogen III synthase (UROS) gene to chromosome 10q25.2----q26.3. | Astrin, KH., et al. 1991. Hum Genet. 87: 18-22. PMID: 2037278
- Human uroporphyrinogen III synthase: molecular cloning, nucleotide sequence, and expression of a full-length cDNA. | Tsai, SF., et al. 1988. Proc Natl Acad Sci U S A. 85: 7049-53. PMID: 3174619
- Purification and properties of uroporphyrinogen III synthase from human erythrocytes. | Tsai, SF., et al. 1987. J Biol Chem. 262: 1268-73. PMID: 3805019
- Uroporphyrinogen-III synthase: molecular cloning, nucleotide sequence, expression of a mouse full-length cDNA, and its localization on mouse chromosome 7. | Xu, W., et al. 1995. Genomics. 26: 556-62. PMID: 7607680
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UROS Antibody (G-9) | sc-365120 | 200 µg/ml | $322.00 | |||
UROS Antibody (G-9): m-IgG Fc BP-HRP Bundle | sc-525857 | 200 µg Ab; 10 µg BP | $361.00 | |||
UROS Antibody (G-9) AC | sc-365120 AC | 500 µg/ml, 25% agarose | $424.00 | |||
UROS Antibody (G-9) HRP | sc-365120 HRP | 200 µg/ml | $322.00 | |||
UROS Antibody (G-9) FITC | sc-365120 FITC | 200 µg/ml | $336.00 | |||
UROS Antibody (G-9) PE | sc-365120 PE | 200 µg/ml | $349.00 | |||
UROS Antibody (G-9) Alexa Fluor® 488 | sc-365120 AF488 | 200 µg/ml | $364.00 | |||
UROS Antibody (G-9) Alexa Fluor® 546 | sc-365120 AF546 | 200 µg/ml | $364.00 | |||
UROS Antibody (G-9) Alexa Fluor® 594 | sc-365120 AF594 | 200 µg/ml | $364.00 | |||
UROS Antibody (G-9) Alexa Fluor® 647 | sc-365120 AF647 | 200 µg/ml | $364.00 | |||
UROS Antibody (G-9) Alexa Fluor® 680 | sc-365120 AF680 | 200 µg/ml | $364.00 | |||
UROS Antibody (G-9) Alexa Fluor® 790 | sc-365120 AF790 | 200 µg/ml | $364.00 |