UROS Inhibitors
UROS inhibitors embody a collection of compounds that either directly target Uroporphyrinogen III synthase or impede its function indirectly through interactions with the overarching heme biosynthesis pathway. The importance of heme synthesis in cellular processes underscores the impact these inhibitors can exert on a myriad of cellular functions.
Succinylacetone and Lead, for instance, directly inhibit aminolevulinic acid dehydratase (ALAD), a precursor enzyme in the pathway. By doing so, they curtail the availability of substrates for subsequent steps, including those catalyzed by UROS. Agents such as Griseofulvin and Hexachlorobenzene disrupt porphyrin metabolism, casting an indirect influence on UROS's activity. Another layer of regulation involves compounds like N-Methylprotoporphyrin that target downstream enzymes, like ferrochelatase. This action can manifest in feedback inhibition on earlier pathway steps. Desferrioxamine, with its iron-chelating capabilities, adds another dimension by affecting iron-dependent stages in the pathway.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adipic acid monoethyl ester | 626-86-8 | sc-233822 | 25 g | $65.00 | ||
A potent inhibitor of aminolevulinic acid dehydratase (ALAD), which is upstream of UROS in the heme synthesis pathway. Inhibiting ALAD reduces substrate availability for UROS. | ||||||
Lead | 7439-92-1 | sc-250236 | 2 kg | $104.00 | ||
Pb^2+ inhibits various enzymes in the heme synthesis pathway including ALAD. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
An antifungal agent that can disrupt porphyrin metabolism, indirectly influencing UROS activity. | ||||||
Succinylacetone | 51568-18-4 | sc-212963 sc-212963B | 10 mg 100 mg | $336.00 $418.00 | ||
Analog of levulinic acid, potentially influencing the heme synthesis pathway. | ||||||
Deferoxamine | 70-51-9 | sc-507390 | 5 mg | $255.00 | ||
Chelates iron and may influence iron-dependent steps in the heme synthesis pathway. | ||||||
Gabaculine | 59556-17-1 | sc-200473 sc-200473A sc-200473B | 10 mg 50 mg 250 mg | $354.00 $884.00 $3069.00 | 5 | |
Inhibits aminolevulinate synthase, reducing substrate availability for the heme synthesis pathway including UROS. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
While primarily a ribonucleotide reductase inhibitor, it might influence the cellular environment and subsequently the heme synthesis pathway. | ||||||