UNC45A Antibody (H-1): sc-390197
- UNC45A Antibody (H-1) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against a peptide mapping at the C-terminus of UNC45A of human origin
- recommended for detection of UNC45A of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for UNC45A Antibody (H-1) for WB applications. These reagents are now offered in bundles with UNC45A Antibody (H-1) (see ordering information below).
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UNC45A Antibody (H-1) is a mouse monoclonal IgG2a antibody that detects UNC45A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UNC45A, also known as SMAP1 or GCUNC45, is a 944 amino acid protein that plays a crucial role as a chaperone for heat shock protein 90 (HSP90), facilitating HSP90′s interaction with the progesterone receptor (PR). This interaction is vital for PR′s proper functioning in cellular processes, including cell proliferation and differentiation. UNC45A is essential for the correct folding of myosin, a key protein in muscle contraction, and is required for normal myotube formation during muscle cell development, highlighting UNC45A′s importance in muscle formation and regeneration. UNC45A is predominantly localized to the perinuclear region of the cytoplasm and is expressed in various tissues, including the spinal cord, bone marrow, peripheral blood leukocytes, trachea, stomach, and adrenal gland. Notably, overexpression of UNC45A has been linked to increased cell proliferation and motility, particularly in ovarian cancer, suggesting UNC45A′s potential role in tumorigenesis. Furthermore, multiple isoforms of UNC45A arise from alternative splicing, which may contribute to UNC45A′s diverse functions in different cellular contexts. Anti-UNC45A antibody (H-1) is an invaluable tool for researchers studying this protein′s intricate roles in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UNC45A Antibody (H-1) | sc-390197 | 200 µg/ml | $322.00 | |||
UNC45A Antibody (H-1): m-IgG Fc BP-HRP Bundle | sc-538067 | 200 µg Ab; 10 µg BP | $361.00 | |||
UNC45A Antibody (H-1): m-IgGκ BP-HRP Bundle | sc-535598 | 200 µg Ab; 40 µg BP | $361.00 | |||
UNC45A Antibody (H-1): m-IgG2a BP-HRP Bundle | sc-548194 | 200 µg Ab; 10 µg BP | $361.00 | |||
UNC45A (H-1) Neutralizing Peptide | sc-390197 P | 100 µg/0.5 ml | $69.00 |