ULBP4 Antibody (6E6): sc-53133
- ULBP4 Antibody (6E6) is a mouse monoclonal IgG2b κ ULBP4 antibody, cited in 11 publications, provided at 200 µg/ml
- raised against purified human ULBP4
- ULBP4 Antibody (6E6) is recommended for detection of ULBP4 of human origin by WB, IP, IF, IHC(P) and FCM
- Anti-ULBP4 Antibody (6E6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also provided azide-free for blocking, sc-53133 L, 200 µg/0.1 ml
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ULBP4 Antibody (6E6) for WB and IHC(P) applications. These reagents are now offered in bundles with ULBP4 Antibody (6E6) (see ordering information below).
ULBP4 Antibody (6E6) is a mouse monoclonal IgG2b kappa light chain antibody that detects the ULBP4 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). ULBP4 (6E6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ULBP4, a member of the UL16 binding protein family, plays a crucial role in the immune response by acting as a ligand for the activating receptor NKG2D/DAP10, which is essential for the activation of natural killer (NK) cells and CD8+ T cells. The interaction between ULBP4 and NKG2D/DAP10 triggers a cascade of signaling events that lead to the secretion of cytokines, such as interferon-gamma, and promotes the lysis of tumor cells. ULBP4 exists as a glycosylphosphatidylinositol (GPI)-anchored protein, localizing to the cell surface and facilitating immune surveillance. ULBP4 expression on stressed or transformed cells serves as a signal for immune recognition, making ULBP4 a critical component in the body′s defense against malignancies and infections. Soluble forms of ULBP4 can modulate immune responses by inducing protein tyrosine phosphorylation and activating key signaling pathways, including Janus kinase 2, STAT5, and phosphatidylinositol 3-kinase/Akt, further underscoring ULBP4′s importance in immune regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ULBP4 Antibody (6E6) References:
- ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. | Cosman, D., et al. 2001. Immunity. 14: 123-33. PMID: 11239445
- ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells. | Kubin, M., et al. 2001. Eur J Immunol. 31: 1428-37. PMID: 11465099
- Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. | Steinle, A., et al. 2001. Immunogenetics. 53: 279-87. PMID: 11491531
- UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. | Sutherland, CL., et al. 2002. J Immunol. 168: 671-9. PMID: 11777960
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ULBP4 Antibody (6E6) | sc-53133 | 200 µg/ml | $316.00 | |||
ULBP4 Antibody (6E6): m-IgG Fc BP-HRP Bundle | sc-528552 | 200 µg Ab; 10 µg BP | $354.00 | |||
ULBP4 Antibody (6E6): m-IgGκ BP-HRP Bundle | sc-520951 | 200 µg Ab, 40 µg BP | $354.00 | |||
ULBP4 Antibody (6E6): m-IgG2b BP-HRP Bundle | sc-550051 | 200 µg Ab; 10 µg BP | $354.00 | |||
ULBP4 Antibody (6E6) L | sc-53133 L | 200 µg/0.1 ml | $316.00 | |||
ULBP4 Antibody (6E6) AC | sc-53133 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ULBP4 Antibody (6E6) HRP | sc-53133 HRP | 200 µg/ml | $316.00 | |||
ULBP4 Antibody (6E6) FITC | sc-53133 FITC | 200 µg/ml | $330.00 | |||
ULBP4 Antibody (6E6) PE | sc-53133 PE | 200 µg/ml | $343.00 | |||
ULBP4 Antibody (6E6) Alexa Fluor® 488 | sc-53133 AF488 | 200 µg/ml | $357.00 | |||
ULBP4 Antibody (6E6) Alexa Fluor® 546 | sc-53133 AF546 | 200 µg/ml | $357.00 | |||
ULBP4 Antibody (6E6) Alexa Fluor® 594 | sc-53133 AF594 | 200 µg/ml | $357.00 | |||
ULBP4 Antibody (6E6) Alexa Fluor® 647 | sc-53133 AF647 | 200 µg/ml | $357.00 | |||
ULBP4 Antibody (6E6) Alexa Fluor® 680 | sc-53133 AF680 | 200 µg/ml | $357.00 | |||
ULBP4 Antibody (6E6) Alexa Fluor® 790 | sc-53133 AF790 | 200 µg/ml | $357.00 |