ULBP3 Antibody (D-1): sc-390844
- ULBP3 Antibody (D-1) is a mouse monoclonal IgG1 κ ULBP3 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 173-217 mapping near the C-terminus of ULBP3 of human origin
- ULBP3 Antibody (D-1) is recommended for detection of ULBP3 of human origin by WB, IP, IF and ELISA
- Anti-ULBP3 Antibody (D-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ULBP3 Antibody (D-1) for WB applications. These reagents are now offered in bundles with ULBP3 Antibody (D-1) (see ordering information below).
ULBP3 Antibody (D-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects ULBP3 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ULBP3 (D-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ULBP3, a member of the UL16 binding protein family, plays a crucial role in the immune response by acting as a ligand for the activating receptor NKG2D/DAP10, which is essential for the activation of natural killer (NK) cells and CD8+ T cells. This interaction triggers the secretion of pro-inflammatory cytokines, such as interferon-gamma, and promotes the lysis of tumor cells, thereby contributing to the immune system′s ability to detect and eliminate transformed or infected cells. The importance of ULBP3 lies not only in its role as a stress-induced ligand that enhances immune surveillance but also in its ability to activate various signaling pathways, including Janus kinase 2, STAT5, and mitogen-activated protein kinase, which are vital for the proliferation and activation of immune cells. Furthermore, the soluble form of UL16 can inhibit the interaction between ULBP3 and NKG2D, highlighting the regulatory mechanisms that modulate immune responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ULBP3 Antibody (D-1) References:
- ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. | Cosman, D., et al. 2001. Immunity. 14: 123-33. PMID: 11239445
- ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells. | Kubin, M., et al. 2001. Eur J Immunol. 31: 1428-37. PMID: 11465099
- Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. | Steinle, A., et al. 2001. Immunogenetics. 53: 279-87. PMID: 11491531
- UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. | Sutherland, CL., et al. 2002. J Immunol. 168: 671-9. PMID: 11777960
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ULBP3 Antibody (D-1) | sc-390844 | 200 µg/ml | $322.00 | |||
ULBP3 Antibody (D-1): m-IgG Fc BP-HRP Bundle | sc-530282 | 200 µg Ab; 10 µg BP | $361.00 | |||
ULBP3 Antibody (D-1): m-IgGκ BP-HRP Bundle | sc-523704 | 200 µg Ab, 40 µg BP | $361.00 | |||
ULBP3 Antibody (D-1): m-IgG1 BP-HRP Bundle | sc-543972 | 200 µg Ab; 20 µg BP | $361.00 | |||
ULBP3 Antibody (D-1) AC | sc-390844 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ULBP3 Antibody (D-1) HRP | sc-390844 HRP | 200 µg/ml | $322.00 | |||
ULBP3 Antibody (D-1) FITC | sc-390844 FITC | 200 µg/ml | $336.00 | |||
ULBP3 Antibody (D-1) PE | sc-390844 PE | 200 µg/ml | $349.00 | |||
ULBP3 Antibody (D-1) Alexa Fluor® 488 | sc-390844 AF488 | 200 µg/ml | $364.00 | |||
ULBP3 Antibody (D-1) Alexa Fluor® 546 | sc-390844 AF546 | 200 µg/ml | $364.00 | |||
ULBP3 Antibody (D-1) Alexa Fluor® 594 | sc-390844 AF594 | 200 µg/ml | $364.00 | |||
ULBP3 Antibody (D-1) Alexa Fluor® 647 | sc-390844 AF647 | 200 µg/ml | $364.00 | |||
ULBP3 Antibody (D-1) Alexa Fluor® 680 | sc-390844 AF680 | 200 µg/ml | $364.00 | |||
ULBP3 Antibody (D-1) Alexa Fluor® 790 | sc-390844 AF790 | 200 µg/ml | $364.00 |