UFSP2 Antibody (C-7): sc-376045
- UFSP2 Antibody (C-7) is a mouse monoclonal IgG2b (lambda light chain) provided at 200 µg/ml
- raised against amino acids 155-340 mapping within an internal region of UFSP2 of human origin
- recommended for detection of UFSP2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for UFSP2 Antibody (C-7) for WB and IHC(P) applications. This reagent is now offered in a bundle with UFSP2 Antibody (C-7) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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UFSP2 Antibody (C-7) is a mouse monoclonal IgG2b antibody that detects UFSP2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). UFSP2, or Ufm1-specific protease 2, is a crucial 469 amino acid thiol protease that plays a significant role in the UFM1 conjugation pathway by specifically cleaving the UFM1 precursor, which is essential for exposing its conserved C-terminal glycine. This step is vital for the subsequent conjugation of UFM1 to target proteins, thereby influencing various cellular processes such as protein stability, localization, and function. UFSP2 (C-7) antibody can detect UFM1 release from UFM1-conjugated proteins, further underscoring UFSP2′s importance in regulating the UFM1 modification cycle, which is implicated in cellular stress responses and the modulation of protein interactions. The gene encoding UFSP2 is located on human chromosome 4, a region known for its large gene deserts and associations with several genetic disorders, including Huntington′s disease and polycystic kidney disease. UFSP2 (C-7) monoclonal antibody serves as an invaluable tool for researchers investigating the dynamics of UFM1 modifications and their implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UFSP2 Antibody (C-7) | sc-376045 | 200 µg/ml | $316.00 | |||
UFSP2 Antibody (C-7): m-IgGλ BP-HRP Bundle | sc-522831 | 200 µg Ab, 40 µg BP | $354.00 |