UFSP2 Inhibitors
UFSP2 inhibitors are chemical entities designed to selectively impede the activity of the UFSP2 (Ubiquitin Fold Modifier 1 Specific Peptidase 2) enzyme. UFSP2 is part of the ubiquitin-like modifier system, which is involved in the post-translational modification of proteins. This specific enzyme has a critical role in the processing of the ubiquitin-like protein UFM1 (Ubiquitin-Fold Modifier 1), which is conjugated to target proteins through a process known as ufmylation. UFSP2 is responsible for the maturation of UFM1 precursors into their active form by cleaving the C-terminal tails and for the deconjugation of UFM1 from modified substrates. UFSP2 inhibitors, by their action, can potentially modulate the ufmylation process by affecting the availability of active UFM1 or altering the dynamics of UFM1 conjugation and deconjugation to substrates.
The mechanism by which UFSP2 inhibitors function involves the binding to the active site or other regulatory regions of the UFSP2 enzyme, which blocks its peptidase activity. The specificity of these inhibitors is paramount to ensure that the interaction with UFSP2 does not inadvertently affect other proteases or enzymes within the cell. Chemists and molecular biologists utilize knowledge of the enzyme's structure, often determined through techniques like X-ray crystallography or NMR spectroscopy, to design inhibitors that fit precisely into the active site. These molecules often mimic the structure of the enzyme's natural substrates or transition states, enabling them to compete effectively with the enzyme's intended substrates.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that can lead to an accumulation of ubiquitinated proteins, possibly causing a compensatory upregulation in other proteasome-related enzymes and impacting UFSP2 indirectly. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A peptide aldehyde that inhibits the proteasome and can cause a buildup of polyubiquitinated proteins. This accumulation may indirectly affect UFSP2 by altering cellular proteostasis and stress responses. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
A selective proteasome inhibitor that can lead to an increase in ubiquitin-protein conjugates, potentially influencing the function of UFSP2 by perturbing the ubiquitin-proteasome system. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
A steroidal lactone that acts as an inhibitor of the proteasomal activity and induces the production of heat shock proteins, which might indirectly affect UFSP2 by modulating cellular responses to misfolded proteins. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
An antimalarial agent that raises the pH in lysosomes, potentially affecting the degradation pathways of cellular proteins and indirectly impacting the activity of UFSP2 by altering the cellular degradation landscape. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
A psychotropic agent that can affect autophagy and endocytosis, potentially altering the turnover of cellular proteins and thus, indirectly influencing UFSP2 activity by changing the dynamics of protein degradation and synthesis. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
An autophagy inhibitor that can impact the catabolism of cellular components and may indirectly affect UFSP2 by modifying the autophagic degradation of protein substrates. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A potent inhibitor of phosphoinositide 3-kinases that can impede autophagy, potentially influencing UFSP2 by altering the balance of protein synthesis and degradation in the cell. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A chemical inhibitor of PI3K that can disrupt autophagy, potentially impacting UFSP2 activity by altering the cellular response to protein aggregates and misfolded proteins. | ||||||
PIK-75, hydrochloride | 372196-77-5 | sc-296089 sc-296089A | 1 mg 5 mg | $28.00 $122.00 | ||
An inhibitor of ER-associated degradation (ERAD) that can influence the degradation of misfolded proteins and potentially affect UFSP2 by modifying the endoplasmic reticulum-associated protein degradation pathway. | ||||||