UFSP1 Antibody (H-3): sc-398577
- UFSP1 Antibody (H-3) is a mouse monoclonal IgG1 κ UFSP1 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 4-57 mapping near the N-terminus of UFSP1 of human origin
- UFSP1 Antibody (H-3) is recommended for detection of UFSP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-UFSP1 Antibody (H-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for UFSP1 Antibody (H-3) for WB applications. These reagents are now offered in bundles with UFSP1 Antibody (H-3) (see ordering information below).
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UFSP1 Antibody (H-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects UFSP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UFSP1 (H-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. UFSP1, also known as Ufm1-specific protease 1, plays a crucial role in the UFM1 conjugation pathway, which is essential for regulating protein stability and function within the cell. Specifically, UFSP1 is a 142 amino acid thiol protease that cleaves the UFM1 precursor, exposing its conserved C-terminal glycine, a necessary step for the subsequent conjugation of UFM1 to target proteins. This process is vital for cellular homeostasis, as UFM1 modification can influence various cellular processes, including stress responses and protein degradation. The gene encoding UFSP1 is located on human chromosome 7, a region associated with several genetic disorders, highlighting the importance of UFSP1 in maintaining cellular integrity and its potential implications in disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
UFSP1 Antibody (H-3) References:
- Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. | Wilson, MD., et al. 2001. Nucleic Acids Res. 29: 1352-65. PMID: 11239002
- A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. | Komatsu, M., et al. 2004. EMBO J. 23: 1977-86. PMID: 15071506
- Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. | Kang, SH., et al. 2007. J Biol Chem. 282: 5256-62. PMID: 17182609
- Structural basis for Ufm1 processing by UfSP1. | Ha, BH., et al. 2008. J Biol Chem. 283: 14893-900. PMID: 18321862
- A novel type of E3 ligase for the Ufm1 conjugation system. | Tatsumi, K., et al. 2010. J Biol Chem. 285: 5417-27. PMID: 20018847
- Genome-wide association analysis identifies multiple loci related to resting heart rate. | Eijgelsheim, M., et al. 2010. Hum Mol Genet. 19: 3885-94. PMID: 20639392
- The ligation systems for ubiquitin and ubiquitin-like proteins. | Tanaka, K., et al. 1998. Mol Cells. 8: 503-12. PMID: 9856335
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UFSP1 Antibody (H-3) | sc-398577 | 200 µg/ml | $322.00 | |||
UFSP1 Antibody (H-3): m-IgG Fc BP-HRP Bundle | sc-530851 | 200 µg Ab; 10 µg BP | $361.00 | |||
UFSP1 Antibody (H-3): m-IgGκ BP-HRP Bundle | sc-524399 | 200 µg Ab, 40 µg BP | $361.00 | |||
UFSP1 Antibody (H-3): m-IgG1 BP-HRP Bundle | sc-544279 | 200 µg Ab; 20 µg BP | $361.00 | |||
UFSP1 Antibody (H-3) AC | sc-398577 AC | 500 µg/ml, 25% agarose | $424.00 | |||
UFSP1 Antibody (H-3) HRP | sc-398577 HRP | 200 µg/ml | $322.00 | |||
UFSP1 Antibody (H-3) FITC | sc-398577 FITC | 200 µg/ml | $336.00 | |||
UFSP1 Antibody (H-3) PE | sc-398577 PE | 200 µg/ml | $349.00 | |||
UFSP1 Antibody (H-3) Alexa Fluor® 488 | sc-398577 AF488 | 200 µg/ml | $364.00 | |||
UFSP1 Antibody (H-3) Alexa Fluor® 546 | sc-398577 AF546 | 200 µg/ml | $364.00 | |||
UFSP1 Antibody (H-3) Alexa Fluor® 594 | sc-398577 AF594 | 200 µg/ml | $364.00 | |||
UFSP1 Antibody (H-3) Alexa Fluor® 647 | sc-398577 AF647 | 200 µg/ml | $364.00 | |||
UFSP1 Antibody (H-3) Alexa Fluor® 680 | sc-398577 AF680 | 200 µg/ml | $364.00 | |||
UFSP1 Antibody (H-3) Alexa Fluor® 790 | sc-398577 AF790 | 200 µg/ml | $364.00 |