Uev1A/Mms2 Antibody (G-6): sc-514420

Uev1A/Mms2 Antibody (G-6) is a mouse monoclonal IgG1 antibody that detects Uev1A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Uev1A, also known as ubiquitin-conjugating enzyme E2 variant 1, plays a crucial role in protein degradation and cellular signaling pathways, particularly in DNA repair and stress responses. Although Uev1A lacks the critical cysteine residue necessary for traditional ubiquitin-conjugating activity, Uev1A collaborates with TRAF6 to facilitate unique polyubiquitin chains linked through Lysine 63 of ubiquitin, which are essential for various cellular processes, including inflammatory responses and genomic stability maintenance. Uev1A′s localization to the nucleus, while excluding nucleolar regions, underscores Uev1A′s importance in nuclear signaling and potential influence on gene expression. Anti-Uev1A/Mms2 antibody (G-6) serves as an invaluable tool for researchers investigating ubiquitin-like proteins in cellular mechanisms and disease states.

The preferred Uev1A antibody is Uev1A Antibody (H-6): sc-390047.