Uev1A Antibody (H-6): sc-390047
- Uev1A Antibody (H-6) is a mouse monoclonal IgG1 κ Uev1A antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 159-191 near the C-terminus of Uev1A of human origin
- Uev1A Antibody (H-6) is recommended for detection of Uev1A isoforms 1, 2, 3, 4 and 5 of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- Anti-Uev1A Antibody (H-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Uev1A Antibody (H-6) for WB and IHC(P) applications. These reagents are now offered in bundles with Uev1A Antibody (H-6) (see ordering information below).
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Uev1A Antibody (H-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Uev1A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Uev1A (H-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Uev1A, also known as UBE2V1 for Ubiquitin-conjugating enzyme E2 variant 1 and CROC1, plays a key role in the ubiquitin-proteasome system, where Uev1A interacts with TRAF6, a RING domain protein, to facilitate the synthesis of unique polyubiquitin chains linked through lysine-63 of ubiquitin. This specific linkage drives various cellular processes, including signal transduction and DNA repair, by helping regulate protein degradation and cellular responses to stress. While Uev1A lacks ubiquitin-conjugating activity in vitro due to missing a conserved cysteine residue, Uev1A expression in colon carcinoma cells inhibits differentiation upon confluence, suggesting a potential role in cancer biology. Located on human chromosome 20q13.2, Uev1A serves critical functions in cellular regulation and disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Uev1A Antibody (H-6) References:
- Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. | Hofmann, RM. and Pickart, CM. 1999. Cell. 96: 645-53. PMID: 10089880
- Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. | Deng, L., et al. 2000. Cell. 103: 351-61. PMID: 11057907
- Interactions within the ubiquitin pathway of Caenorhabditis elegans. | Gudgen, M., et al. 2004. Biochem Biophys Res Commun. 325: 479-86. PMID: 15530417
- CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter. | Rothofsky, ML. and Lin, SL. 1997. Gene. 195: 141-9. PMID: 9305758
- Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. | Sancho, E., et al. 1998. Mol Cell Biol. 18: 576-89. PMID: 9418904
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Uev1A Antibody (H-6) | sc-390047 | 200 µg/ml | $322.00 | |||
Uev1A Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-523383 | 200 µg Ab, 40 µg BP | $361.00 | |||
Uev1A Antibody (H-6): m-IgG1 BP-HRP Bundle | sc-533575 | 200 µg Ab; 20 µg BP | $361.00 | |||
Uev1A Antibody (H-6) AC | sc-390047 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Uev1A Antibody (H-6) HRP | sc-390047 HRP | 200 µg/ml | $322.00 | |||
Uev1A Antibody (H-6) FITC | sc-390047 FITC | 200 µg/ml | $336.00 | |||
Uev1A Antibody (H-6) PE | sc-390047 PE | 200 µg/ml | $349.00 | |||
Uev1A Antibody (H-6) Alexa Fluor® 488 | sc-390047 AF488 | 200 µg/ml | $364.00 | |||
Uev1A Antibody (H-6) Alexa Fluor® 546 | sc-390047 AF546 | 200 µg/ml | $364.00 | |||
Uev1A Antibody (H-6) Alexa Fluor® 594 | sc-390047 AF594 | 200 µg/ml | $364.00 | |||
Uev1A Antibody (H-6) Alexa Fluor® 647 | sc-390047 AF647 | 200 µg/ml | $364.00 | |||
Uev1A Antibody (H-6) Alexa Fluor® 680 | sc-390047 AF680 | 200 µg/ml | $364.00 | |||
Uev1A Antibody (H-6) Alexa Fluor® 790 | sc-390047 AF790 | 200 µg/ml | $364.00 | |||
Uev1A (H-6) Neutralizing Peptide | sc-390047 P | 100 µg/0.5 ml | $69.00 |