Ubr1 Antibody (24-Z): sc-100626

Ubr1 Antibody (24-Z) is a mouse monoclonal IgG1 antibody that detects Ubr1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Ubr1 plays a crucial role in the N-end rule pathway, which is integral to the ubiquitin-proteasome system responsible for regulating protein degradation based on the identity of the N-terminal residues. This pathway is vital for maintaining cellular homeostasis, as Ubr1 selectively targets proteins for degradation, thereby influencing various cellular processes, including cell cycle regulation, signal transduction, and stress responses. Ubr1 is characterized by two zinc finger domains and a RING-H2 finger domain, which are essential for recognizing substrate proteins and facilitating the attachment of ubiquitin. Ubr1 is ubiquitously expressed in adult human tissues, with particularly high levels found in skeletal muscle and heart, indicating importance in muscle function and overall metabolic regulation. Additionally, during embryonic development, Ubr1 is predominantly expressed in the branchial arches and limb buds, highlighting a role in developmental processes. anti-Ubr1 antibody (24-Z) is an invaluable tool for researchers studying protein degradation pathways and their implications in various biological contexts.

The preferred Ubr1 antibody is Ubr1 Antibody (A-5): sc-515753.