U2AF1L3/35 Antibody (D-4): sc-514459
- U2AF1L3/35 Antibody (D-4) is a mouse monoclonal IgG1 κ U2AF1L3/35 antibody provided at 200 µg/ml
- raised against amino acids 36-186 mapping within an internal region of U2AF35 of human origin
- U2AF1L3/35 Antibody (D-4) is recommended for detection of U2AF1L3 and U2AF35 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-U2AF1L3/35 Antibody (D-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of U2AF1L3/35 (D-4): sc-514459.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for U2AF1L3/35 Antibody (D-4) for WB applications. These reagents are now offered in bundles with U2AF1L3/35 Antibody (D-4) (see ordering information below).
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U2AF1L3/35 Antibody (D-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects U2AF1L3/35 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). U2AF1L3/35 (D-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. U2AF1L3/35 plays a crucial role in pre-mRNA splicing, a vital process for gene expression regulation, as U2AF1L3/35 helps in the recognition of the 3′ splice site during the splicing of introns from pre-mRNA. This function is particularly important because proper splicing is essential for the production of functional proteins, and any dysregulation can lead to various diseases, including cancer. U2AF1L3/35 is located in the nucleus, where U2AF1L3/35 interacts with other splicing factors and components of the spliceosome, further emphasizing U2AF1L3/35′s significance in maintaining cellular homeostasis and gene expression fidelity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
U2AF1L3/35 Antibody (D-4) References:
- Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution. | Müller, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 206-11. PMID: 10618396
- Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart. | Mao, R., et al. 2005. Genome Biol. 6: R107. PMID: 16420667
- BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome. | Sun, X., et al. 2006. FASEB J. 20: 1369-76. PMID: 16816112
- The discovery and mapping to chromosome 21 of the Alzheimer's amyloid gene: history revised. | Robakis, NK. 2006. J Alzheimers Dis. 10: 453-5. PMID: 17183160
- Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts. | Peterson, LF., et al. 2007. Blood. 110: 799-805. PMID: 17412887
- Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes. | Aït Yahya-Graison, E., et al. 2007. Am J Hum Genet. 81: 475-91. PMID: 17701894
- DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease. | Ryoo, SR., et al. 2007. J Biol Chem. 282: 34850-7. PMID: 17906291
- Exclusion of KCNE1 (IsK) as a candidate gene for Jervell and Lange-Nielsen syndrome. | Tesson, F., et al. 1996. J Mol Cell Cardiol. 28: 2051-5. PMID: 8899564
- IsK and KvLQT1: mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome. | Tyson, J., et al. 1997. Hum Mol Genet. 6: 2179-85. PMID: 9328483
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U2AF1L3/35 Antibody (D-4) | sc-514459 | 200 µg/ml | $316.00 | |||
U2AF1L3/35 Antibody (D-4): m-IgG Fc BP-HRP Bundle | sc-531135 | 200 µg Ab; 10 µg BP | $354.00 | |||
U2AF1L3/35 Antibody (D-4): m-IgGκ BP-HRP Bundle | sc-524735 | 200 µg Ab, 40 µg BP | $354.00 | |||
U2AF1L3/35 Antibody (D-4): m-IgG1 BP-HRP Bundle | sc-544412 | 200 µg Ab; 20 µg BP | $354.00 | |||
U2AF1L3/35 Antibody (D-4) AC | sc-514459 AC | 500 µg/ml, 25% agarose | $416.00 | |||
U2AF1L3/35 Antibody (D-4) HRP | sc-514459 HRP | 200 µg/ml | $316.00 | |||
U2AF1L3/35 Antibody (D-4) FITC | sc-514459 FITC | 200 µg/ml | $330.00 | |||
U2AF1L3/35 Antibody (D-4) PE | sc-514459 PE | 200 µg/ml | $343.00 | |||
U2AF1L3/35 Antibody (D-4) Alexa Fluor® 488 | sc-514459 AF488 | 200 µg/ml | $357.00 | |||
U2AF1L3/35 Antibody (D-4) Alexa Fluor® 546 | sc-514459 AF546 | 200 µg/ml | $357.00 | |||
U2AF1L3/35 Antibody (D-4) Alexa Fluor® 594 | sc-514459 AF594 | 200 µg/ml | $357.00 | |||
U2AF1L3/35 Antibody (D-4) Alexa Fluor® 647 | sc-514459 AF647 | 200 µg/ml | $357.00 | |||
U2AF1L3/35 Antibody (D-4) Alexa Fluor® 680 | sc-514459 AF680 | 200 µg/ml | $357.00 | |||
U2AF1L3/35 Antibody (D-4) Alexa Fluor® 790 | sc-514459 AF790 | 200 µg/ml | $357.00 |