Tyrosinase Antibody (6A207): sc-73244
- Tyrosinase Antibody (6A207) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 200 µg/ml
- raised against recombinant Tyrosinase of human origin
- recommended for detection of Tyrosinase of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See Tyrosinase (T311): sc-20035 for Tyrosinase antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Tyrosinase Antibody (6A207) for WB and IHC(P) applications. These reagents are now offered in bundles with Tyrosinase Antibody (6A207) (see ordering information below).
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Tyrosinase Antibody (6A207) is a mouse monoclonal IgG2a antibody that detects tyrosinase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Tyrosinase is a type I membrane protein and a copper-containing enzyme that plays a crucial role in melanin production, the primary pigment in vertebrates. Anti-tyrosinase antibody (6A207) recognizes a protein that catalyzes the essential and rate-limiting step of tyrosine hydroxylation, vital for melanin biosynthesis. Deficiencies in tyrosinase activity can lead to various forms of albinism, highlighting its importance in pigmentation and skin health. Tyrosinase interacts with related proteins such as TRP1 and TRP2, which are also expressed in melanocytes and contribute to melanin synthesis within melanosomes. These proteins share a similar transmembrane structure and contain metal-binding regions, but they exhibit distinct catalytic activities essential for melanin biopolymer formation. The interaction among these proteins suggests they may form a multi-enzyme complex, with TRP1 playing a role in stabilizing tyrosinase within melanocytes, thereby underscoring the intricate network of protein interactions that regulate pigmentation processes. Tyrosinase monoclonal antibody (6A207) serves as an invaluable tool for researchers studying melanin biosynthesis and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.
Download thiomersal SDS
Tyrosinase Antibody (6A207) References:
- Tyrosinase-catalyzed oxidation of fluorophenols. | Battaini, G., et al. 2002. J Biol Chem. 277: 44606-12. PMID: 12235154
- Mutations of the tyrosinase gene in oculocutaneous albinism. | Shibahara, S. 1992. Pigment Cell Res. 5: 279-83. PMID: 1292010
- The nature of tyrosinase isozymes. | Tsukamoto, K., et al. 1992. Pigment Cell Res. Suppl 2: 84-9. PMID: 1409443
- Tyrosinase inhibition kinetics of anisic acid. | Kubo, I., et al. 2003. Z Naturforsch C J Biosci. 58: 713-8. PMID: 14577637
- Inactivation mechanism of tyrosinase in mouse melanoma. | Tomita, Y. and Seiji, M. 1977. J Dermatol. 4: 245-9. PMID: 15461355
- Tyrosinase immobilized on a hydrophobic membrane. | Algieri, C., et al. 2017. Biotechnol Appl Biochem. 64: 92-99. PMID: 26607971
- Characterization of the action of tyrosinase on resorcinols. | Garcia-Jimenez, A., et al. 2016. Bioorg Med Chem. 24: 4434-4443. PMID: 27480027
- Tyrosinase inhibitory flavonoid from Juniperus communis fruits. | Jegal, J., et al. 2016. Biosci Biotechnol Biochem. 80: 2311-2317. PMID: 27492585
- Thiopurine Drugs Repositioned as Tyrosinase Inhibitors. | Choi, J., et al. 2017. Int J Mol Sci. 19: PMID: 29283382
- Valorization of biomass polyphenols as potential tyrosinase inhibitors. | Pham, TN., et al. 2024. Drug Discov Today. 29: 103843. PMID: 38000718
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyrosinase Antibody (6A207) | sc-73244 | 200 µg/ml | $322.00 | |||
Tyrosinase Antibody (6A207): m-IgG Fc BP-HRP Bundle | sc-539465 | 200 µg Ab; 10 µg BP | $361.00 | |||
Tyrosinase Antibody (6A207): m-IgG2a BP-HRP Bundle | sc-546710 | 200 µg Ab; 10 µg BP | $361.00 |