Tyro3 Antibody (B-4): sc-166360

Tyro3 Antibody (B-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Tyro3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Tyro3 (B-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Tyro3 is a member of the Axl/UFO subfamily of receptor tyrosine kinases, which play crucial roles in cellular signaling pathways. These receptors are characterized by their unique structure, which includes an N-terminal extracellular domain composed of two immunoglobulin-like domains and two fibronectin type III domains, followed by a single transmembrane helix and a cytoplasmic tyrosine kinase domain. The structural integrity of Tyro3 is vital for its function in processes such as spermatogenesis, immunoregulation, and phagocytosis, as Tyro3 facilitates receptor dimerization and activation upon ligand binding. Tyro3 is predominantly expressed in adult tissues, particularly in the brain, testis, lymphatic, and vascular systems, highlighting Tyro3′s importance in various physiological functions. Additionally, Tyro3 undergoes significant post-translational modifications, including tyrosine phosphorylation and glycosylation, which are essential for regulatory roles in cellular processes. The interaction of Tyro3 with ligands such as Protein S and Gas6 further underscores functional relevance, as these proteins are implicated in anticoagulant mechanisms and growth regulation, thereby contributing to overall homeostasis within the body.

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Tyro3 Antibody (B-4) References:

1. Deletion of the receptor tyrosine kinase Tyro3 inhibits synovial hyperplasia and bone damage in arthritis.  |  Ruiz-Heiland, G., et al. 2014. Ann Rheum Dis. 73: 771-9. PMID: 23632195
2. Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma.  |  Dantas-Barbosa, C., et al. 2017. Br J Cancer. 117: 1787-1797. PMID: 29024938
3. The TAM receptor TYRO3 is a critical regulator of myelin thickness in the central nervous system.  |  Blades, F., et al. 2018. Glia. 66: 2209-2220. PMID: 30208252
4. Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation.  |  Zhou, J., et al. 2018. Cell Commun Signal. 16: 98. PMID: 30541554
5. The Pros1/Tyro3 axis protects against periodontitis by modulating STAT/SOCS signalling.  |  Jiang, L., et al. 2019. J Cell Mol Med. 23: 2769-2781. PMID: 30729671
6. TYRO3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer.  |  Dufour, F., et al. 2019. Br J Cancer. 120: 555-564. PMID: 30765874
7. Functional Genomics Identifies Hepatitis-Induced STAT3-TYRO3-STAT3 Signaling as a Potential Therapeutic Target of Hepatoma.  |  Tsai, CL., et al. 2020. Clin Cancer Res. 26: 1185-1197. PMID: 31831556
8. TYRO3 facilitates cell growth and metastasis via activation of the Wnt/β-catenin signaling pathway in human gastric cancer cells.  |  Chen, D., et al. 2020. Aging (Albany NY). 12: 2261-2274. PMID: 32018224
9. Identification of signalling pathways activated by Tyro3 that promote cell survival, proliferation and invasiveness in human cancer cells.  |  Al Kafri, N. and Hafizi, S. 2021. Biochem Biophys Rep. 28: 101111. PMID: 34471705
10. The therapeutic effect of GAS6 in remyelination is dependent upon Tyro3.  |  Asadian, N., et al. 2024. Glia. 72: 1392-1401. PMID: 38572807

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tyro3 Antibody (B-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Tyro3 Antibody (B-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tyro3 Antibody (B-4) Specifications

Alternate Product Name: Tyro3

Product Clone Name: B-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 781-890

Epitope Target: Tyro3

Epitope Species: human

Product Reactivity/Detection: Tyro3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Tyro3 Antibody (B-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Tyro3 antibody is Tyro3 Antibody (A-7): sc-166359.