TXNL1 Antibody (D-5): sc-365711
- TXNL1 Antibody (D-5) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 129-164 within an internal region of TXNL1 of human origin
- recommended for detection of TXNL1 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TXNL1 Antibody (D-5) for WB applications. These reagents are now offered in bundles with TXNL1 Antibody (D-5) (see ordering information below).
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TXNL1 Antibody (D-5) is a mouse monoclonal IgG2b antibody that detects TXNL1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TXNL1, also known as Thioredoxin-like protein 1, TRP32, TXL, or TXL-1, is a 289 amino acid cytoplasmic protein that plays a crucial role in cellular redox regulation and endocytotic signaling pathways. TXNL1 is essential for coupling oxidative stress to endocytosis, thereby influencing the GDI:Rad5-mediated endocytic response, which is vital for maintaining cellular homeostasis under stress conditions. Furthermore, TXNL1 has been shown to inhibit cell proliferation by inducing G0/G1 arrest, indicating its function as a transcriptional repressor. TXNL1 exhibits 99% homology with its mouse counterpart and contains a single thioredoxin domain, which is significant for its redox-active properties. anti-TXNL1 antibody (D-5) is a valuable tool for researchers studying the intricate roles of TXNL1 in various biological processes and its implications in disease states.
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TXNL1 Antibody (D-5) References:
- Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome. | Andersen, KM., et al. 2009. J Biol Chem. 284: 15246-54. PMID: 19349277
- HDAC2 and TXNL1 distinguish aneuploid from diploid colorectal cancers. | Gemoll, T., et al. 2011. Cell Mol Life Sci. 68: 3261-74. PMID: 21290163
- TXNL1-XRCC1 pathway regulates cisplatin-induced cell death and contributes to resistance in human gastric cancer. | Xu, W., et al. 2014. Cell Death Dis. 5: e1055. PMID: 24525731
- TXNL1 induces apoptosis in cisplatin resistant human gastric cancer cell lines. | Ni, P., et al. 2015. Curr Cancer Drug Targets. 14: 850-9. PMID: 25348020
- Newcastle disease virus V protein inhibits apoptosis in DF-1 cells by downregulating TXNL1. | Wang, C., et al. 2018. Vet Res. 49: 102. PMID: 30290847
- Up-regulation of antioxidative proteins TRX1, TXNL1 and TXNRD1 in the cortex of PTZ kindling seizure model mice. | Yu, JT., et al. 2019. PLoS One. 14: e0210670. PMID: 30677045
- The role of TXNL1 in disease: treatment strategies for cancer and diseases with oxidative stress. | Zhao, JM. and Qi, TG. 2021. Mol Biol Rep. 48: 2929-2934. PMID: 33660093
- Tat-Thioredoxin-like protein 1 attenuates ischemic brain injury by regulation of MAPKs and apoptosis signaling. | Cha, HJ., et al. 2023. BMB Rep. 56: 234-239. PMID: 36571143
- TXNL1 has dual functions as a redox active thioredoxin-like protein as well as an ATP- and redox-independent chaperone. | Andor, A., et al. 2023. Redox Biol. 67: 102897. PMID: 37804695
- Structural landscape of AAA+ ATPase motor states in the substrate-degrading human 26S proteasome reveals conformation-specific binding of TXNL1. | Arkinson, C., et al. 2024. bioRxiv.. PMID: 39574680
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TXNL1 Antibody (D-5) | sc-365711 | 200 µg/ml | $316.00 | |||
TXNL1 Antibody (D-5): m-IgGκ BP-HRP Bundle | sc-535242 | 200 µg Ab; 40 µg BP | $354.00 | |||
TXNL1 Antibody (D-5): m-IgG2b BP-HRP Bundle | sc-549375 | 200 µg Ab; 10 µg BP | $354.00 | |||
TXNL1 (D-5) Neutralizing Peptide | sc-365711 P | 100 µg/0.5 ml | $68.00 |