TTP Antibody (H-12): sc-398904
- TTP Antibody (H-12) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 287-302 near the C-terminus of TTP of human origin
- recommended for detection of TTP of mouse, rat and human origin by WB, IP, IF and ELISA
- See TTP (A-8): sc-374305 for TTP antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TTP Antibody (H-12) for WB applications. These reagents are now offered in bundles with TTP Antibody (H-12) (see ordering information below).
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SEE ALSO...
TTP Antibody (H-12) is a mouse monoclonal IgG2b antibody that detects tristetraprolin (TTP) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TTP is a crucial zinc-binding protein encoded by the immediate-early response gene Zfp-36, playing a significant role in the regulation of mRNA stability and inflammatory responses. TTP (H-12) antibody recognizes a protein essential for post-transcriptional regulation of pro-inflammatory cytokines, particularly tumor necrosis factor-alpha (TNF-α), which maintains immune homeostasis. TTP′s binding to AU-rich elements in the 3′ untranslated region of target mRNAs leads to their degradation, preventing excessive inflammation. Phosphorylation of TTP by p42 MAP kinase upon mitogen stimulation results in translocation from the nucleus to the cytoplasm, highlighting dynamic regulation in response to cellular signals. Studies using knockout mice deficient in TTP have revealed a propensity for developing autoimmune conditions, such as inflammatory arthritis and dermatitis, which can be mitigated by inhibiting TNF-α activity, underscoring TTP′s essential role in modulating inflammatory processes. Anti-TTP antibody (H-12) serves as an invaluable tool for researchers investigating the intricate mechanisms of inflammation and immune regulation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TTP Antibody (H-12) | sc-398904 | 200 µg/ml | $316.00 | |||
TTP Antibody (H-12): m-IgGκ BP-HRP Bundle | sc-536175 | 200 µg Ab; 40 µg BP | $354.00 | |||
TTP Antibody (H-12): m-IgG2b BP-HRP Bundle | sc-549522 | 200 µg Ab; 10 µg BP | $354.00 | |||
TTP (H-12) Neutralizing Peptide | sc-398904 P | 100 µg/0.5 ml | $68.00 |