TTK Antibody (N1): sc-56968
- TTK Antibody (N1) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 3-856 of TTK of human origin
- recommended for detection of TTK of human origin by WB, IP and IF
- Anti-TTK Antibody (N1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TTK Antibody (N1) for WB applications. These reagents are now offered in bundles with TTK Antibody (N1) (see ordering information below).
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TTK (N1) is a mouse monoclonal IgG1 kappa light chain antibody that detects TTK of human origin by western blotting (WB), immunoprecipitation (IP) and immunofluorescence (IF). Anti-TTK antibody (N1) is available as non-conjugated form, as well as multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC) and multiple Alexa Fluor® conjugates. Progression of cells through the cell cycle is regulated by variations in levels and activities of protein kinases and by oscillation in levels of regulatory subunits (i.e., cyclins). The full length sequence for a unique protein kinase of human origin, designated TTK, was cloned by screening a T cell expression library with anti-phosphotyrosine antibodies. Similarly, the mouse homolog of TTK was isolated from an embryonal carcinoma (EC) cell line by expression cloning. TTK/Esk are novel members of the serine-threonine/tyrosine family of protein kinases and are expressed in a broad range of proliferating human cells and tissues. TTK-Esk expression is reduced or absent in resting cells and in cells with a low proliferative index. When cells are induced to enter the cell cycle, levels of TTK mRNA, protein and kinase activity increase at the G1 to S phase and peak in the G2 to M phase, suggesting TTK/Esk may function as cell cycle regulatory components.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TTK Antibody (N1) References:
- TTK Inhibitors as a Targeted Therapy for CTNNB1 (β-catenin) Mutant Cancers. | Zaman, GJR., et al. 2017. Mol Cancer Ther. 16: 2609-2617. PMID: 28751540
- TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination. | Chandler, BC., et al. 2020. J Clin Invest. 130: 958-973. PMID: 31961339
- TTK inhibitor promotes radiosensitivity of liver cancer cells through p21. | Zhang, H., et al. 2021. Biochem Biophys Res Commun. 550: 84-91. PMID: 33689884
- TTK inhibition increases cisplatin sensitivity in high-grade serous ovarian carcinoma through the mTOR/autophagy pathway. | Qi, G., et al. 2021. Cell Death Dis. 12: 1135. PMID: 34876569
- TTK Protein Kinase promotes temozolomide resistance through inducing autophagy in glioblastoma. | Yu, J., et al. 2022. BMC Cancer. 22: 786. PMID: 35850753
- Integrated multi-omics analyses and functional validation reveal TTK as a novel EMT activator for endometrial cancer. | Miao, Y., et al. 2023. J Transl Med. 21: 151. PMID: 36829176
- Therapeutic targeting of the TPX2/TTK network in colorectal cancer. | Shaath, H., et al. 2023. Cell Commun Signal. 21: 265. PMID: 37770979
- Discovery of a potent and selective covalent threonine tyrosine kinase (TTK) inhibitor. | Sun, Y., et al. 2024. Bioorg Chem. 143: 107053. PMID: 38159497
- Annexin A2 combined with TTK accelerates esophageal cancer progression via the Akt/mTOR signaling pathway. | Liu, R., et al. 2024. Cell Death Dis. 15: 291. PMID: 38658569
- TTK inhibitor OSU13 promotes immunotherapy responses by activating tumor STING. | Bharti, V., et al. 2024. JCI Insight. 9: PMID: 38900577
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TTK Antibody (N1) | sc-56968 | 200 µg/ml | $322.00 | |||
TTK Antibody (N1): m-IgG Fc BP-HRP Bundle | sc-537131 | 200 µg Ab; 10 µg BP | $361.00 | |||
TTK Antibody (N1): m-IgGκ BP-HRP Bundle | sc-534323 | 200 µg Ab; 40 µg BP | $361.00 | |||
TTK Antibody (N1): m-IgG1 BP-HRP Bundle | sc-545022 | 200 µg Ab; 20 µg BP | $361.00 | |||
TTK Antibody (N1) AC | sc-56968 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TTK Antibody (N1) HRP | sc-56968 HRP | 200 µg/ml | $322.00 | |||
TTK Antibody (N1) FITC | sc-56968 FITC | 200 µg/ml | $336.00 | |||
TTK Antibody (N1) PE | sc-56968 PE | 200 µg/ml | $349.00 | |||
TTK Antibody (N1) Alexa Fluor® 488 | sc-56968 AF488 | 200 µg/ml | $364.00 | |||
TTK Antibody (N1) Alexa Fluor® 546 | sc-56968 AF546 | 200 µg/ml | $364.00 | |||
TTK Antibody (N1) Alexa Fluor® 594 | sc-56968 AF594 | 200 µg/ml | $364.00 | |||
TTK Antibody (N1) Alexa Fluor® 647 | sc-56968 AF647 | 200 µg/ml | $364.00 | |||
TTK Antibody (N1) Alexa Fluor® 680 | sc-56968 AF680 | 200 µg/ml | $364.00 | |||
TTK Antibody (N1) Alexa Fluor® 790 | sc-56968 AF790 | 200 µg/ml | $364.00 |