Transcription Termination Factor 2/TTF2 Antibody (B-2): sc-514996

TTF2 Antibody (B-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects TTF2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TTF2 monoclonal antibody (B-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TTF2, or Transcription Termination Factor 2, is a double-stranded DNA-dependent ATPase that plays a crucial role in transcription termination by coupling ATP hydrolysis with the release of RNA polymerase II from the DNA template, effectively halting transcription. TTF2 is primarily localized to the cytoplasm during interphase and translocates to the nucleus during mitosis, highlighting its dynamic role in cellular processes. TTF2 is a member of the Swi2/Snf2 protein family and is also implicated in pre-mRNA splicing and mitotic transcriptional repression, making TTF2 essential for proper gene expression regulation. TTF2 features a helicase ATP-binding domain and interacts with the spliceosome complex and Cdc5L (cell division cycle 5-like), further emphasizing TTF2′s multifaceted functions in cellular biology. Additionally, TTF2 exists in two isoforms due to alternative splicing, which may contribute to TTF2′s diverse regulatory roles in transcription and RNA processing.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Transcription Termination Factor 2/TTF2 Antibody (B-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Transcription Termination Factor 2/TTF2 Antibody (B-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Transcription Termination Factor 2/TTF2 Antibody (B-2) Specifications

Alternate Product Name: TTF2

Product Clone Name: B-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-300

Epitope Target: TTF2

Epitope Species: human

Product Reactivity/Detection: TTF2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Transcription Termination Factor 2/TTF2 Antibody (B-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Transcription Termination Factor 2/TTF2 antibody is Transcription Termination Factor 2/TTF2 Antibody (A-9): sc-393478.