TTC12 Antibody (E-8): sc-390241

TTC12 Antibody (E-8) is a mouse monoclonal IgG2b antibody that detects TTC12 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TTC12, also known as TPARM, is a 705 amino acid cytoplasmic protein characterized by its tetratricopeptide repeat domain and three armadillo repeat motifs, which play a crucial role in mediating protein-protein interactions essential for various cellular pathways. The presence of the TPR motif allows TTC12 to engage in specific interactions with other proteins, influencing processes such as cell signaling and gene regulation. TTC12 is expressed in several tissues, including the testis, prostate, lung, and various cancer types, highlighting potential significance in tumor biology. The gene encoding TTC12 is located on human chromosome 11, a region frequently deleted in various cancers, suggesting TTC12 may function as a candidate tumor suppressor gene. Given involvement in critical cellular functions and association with cancer, anti-TTC12 antibody (E-8) serves as a valuable tool for researchers investigating this protein in health and disease.

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TTC12 Antibody (E-8) References:

1. Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations.  |  Gelernter, J., et al. 2006. Hum Mol Genet. 15: 3498-507. PMID: 17085484
2. Hypermethylation of TTC12 gene in acute lymphoblastic leukemia.  |  Wattanawaraporn, R., et al. 2007. Leukemia. 21: 2370-3. PMID: 17657212
3. TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood.  |  Ducci, F., et al. 2011. Biol Psychiatry. 69: 650-60. PMID: 21168125
4. ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure.  |  Nelson, EC., et al. 2013. JAMA Psychiatry. 70: 325-33. PMID: 23303482
5. NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence.  |  Bidwell, LC., et al. 2015. Psychopharmacology (Berl). 232: 1177-86. PMID: 25273375
6. NCAM1-TTC12-ANKK1-DRD2 gene cluster and the clinical and genetic heterogeneity of adults with ADHD.  |  Mota, NR., et al. 2015. Am J Med Genet B Neuropsychiatr Genet. 168: 433-444. PMID: 25989041
7. A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response.  |  Macare, C., et al. 2018. Eur Neuropsychopharmacol. 28: 1103-1114. PMID: 30104163
8. TTC12 Loss-of-Function Mutations Cause Primary Ciliary Dyskinesia and Unveil Distinct Dynein Assembly Mechanisms in Motile Cilia Versus Flagella.  |  Thomas, L., et al. 2020. Am J Hum Genet. 106: 153-169. PMID: 31978331
9. Biallelic mutations of TTC12 and TTC21B were identified in Chinese patients with multisystem ciliopathy syndromes.  |  Chen, W., et al. 2022. Hum Genomics. 16: 48. PMID: 36273201
10. Novel homozygous variants in TTC12 cause male infertility with asthenoteratozoospermia owing to dynein arm complex and mitochondrial sheath defects in flagella.  |  Meng, L., et al. 2023. Front Cell Dev Biol. 11: 1184331. PMID: 37325566

The preferred TTC12 antibody is TTC12 Antibody (B-1): sc-390229.