TSPAN1 Antibody (B-9): sc-376551
- TSPAN1 Antibody (B-9) is a mouse monoclonal IgG1 κ TSPAN1 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 150-241 mapping at the C-terminus of TSPAN1 of human origin
- TSPAN1 Antibody (B-9) is recommended for detection of TSPAN1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TSPAN1 Antibody (B-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TSPAN1 Antibody (B-9) for WB and IHC(P) applications. These reagents are now offered in bundles with TSPAN1 Antibody (B-9) (see ordering information below).
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TSPAN1 Antibody (B-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects TSPAN1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-TSPAN1 antibody (B-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TSPAN1, also known as tetraspanin 1, NET1, TM4C, or TM4SF, is a 241 amino acid multi-pass membrane protein primarily localized to the lysosomal membrane, which is crucial for its role in cellular processes. The lysosome is essential for the degradation and recycling of cellular components, and TSPAN1′s localization suggests involvement in regulating lysosomal function and trafficking. TSPAN1 is overexpressed in various human cancers, indicating potential role in tumor progression, particularly in colon cancer and gastric cancer cell migration and invasion. TSPAN1 may function as a breast cancer suppressor gene, highlighting importance in cancer biology. The gene encoding TSPAN1 is located on human chromosome 1p34.1, which spans approximately 260 million base pairs and contains around 3,000 genes, underscoring the complexity and significance of this genomic region in human health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TSPAN1 Antibody (B-9) References:
- Clinicopathological significance of overexpression of TSPAN1, Ki67 and CD34 in gastric carcinoma. | Chen, L., et al. 2008. Tumori. 94: 531-8. PMID: 18822690
- Tspan-1 is a tetraspanin preferentially expressed by mucinous and endometrioid subtypes of human ovarian carcinomas. | Scholz, CJ., et al. 2009. Cancer Lett. 275: 198-203. PMID: 19017553
- TSPAN1 protein expression: a significant prognostic indicator for patients with colorectal adenocarcinoma. | Chen, L., et al. 2009. World J Gastroenterol. 15: 2270-6. PMID: 19437569
- Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum. | Scholz, CJ., et al. 2009. Protein Pept Lett. 16: 1244-8. PMID: 19508227
- Knockdown of TSPAN1 by RNA silencing and antisense technique inhibits proliferation and infiltration of human skin squamous carcinoma cells. | Chen, L., et al. 2010. Tumori. 96: 289-95. PMID: 20572588
- Clinicopathological significance of expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma. | Chen, L., et al. 2010. J Korean Med Sci. 25: 1438-42. PMID: 20890423
- A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer. | Bennett, G., et al. 2011. BMC Cancer. 11: 50. PMID: 21284875
- Suppression of TSPAN1 by RNA interference inhibits proliferation and invasion of colon cancer cells in vitro. | Chen, L., et al. 2010. Tumori. 96: 744-50. PMID: 21302622
- Sequences and expression of six new members of the tetraspanin/TM4SF family. | Todd, SC., et al. 1998. Biochim Biophys Acta. 1399: 101-4. PMID: 9714763
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TSPAN1 Antibody (B-9) | sc-376551 | 200 µg/ml | $322.00 | |||
TSPAN1 Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-529905 | 200 µg Ab; 10 µg BP | $361.00 | |||
TSPAN1 Antibody (B-9): m-IgGκ BP-HRP Bundle | sc-523004 | 200 µg Ab, 40 µg BP | $361.00 | |||
TSPAN1 Antibody (B-9): m-IgG1 BP-HRP Bundle | sc-543758 | 200 µg Ab; 20 µg BP | $361.00 | |||
TSPAN1 Antibody (B-9) AC | sc-376551 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TSPAN1 Antibody (B-9) HRP | sc-376551 HRP | 200 µg/ml | $322.00 | |||
TSPAN1 Antibody (B-9) FITC | sc-376551 FITC | 200 µg/ml | $336.00 | |||
TSPAN1 Antibody (B-9) PE | sc-376551 PE | 200 µg/ml | $349.00 | |||
TSPAN1 Antibody (B-9) Alexa Fluor® 488 | sc-376551 AF488 | 200 µg/ml | $364.00 | |||
TSPAN1 Antibody (B-9) Alexa Fluor® 546 | sc-376551 AF546 | 200 µg/ml | $364.00 | |||
TSPAN1 Antibody (B-9) Alexa Fluor® 594 | sc-376551 AF594 | 200 µg/ml | $364.00 | |||
TSPAN1 Antibody (B-9) Alexa Fluor® 647 | sc-376551 AF647 | 200 µg/ml | $364.00 | |||
TSPAN1 Antibody (B-9) Alexa Fluor® 680 | sc-376551 AF680 | 200 µg/ml | $364.00 | |||
TSPAN1 Antibody (B-9) Alexa Fluor® 790 | sc-376551 AF790 | 200 µg/ml | $364.00 |