TSG-6 Antibody (D-4): sc-398307

TSG-6 Antibody (D-4) is a mouse monoclonal IgG2b kappa light chain antibody designed to detect TSG-6, also known as TNFAIP6, in human samples using western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) applications. TSG-6 is a critical extracellular glycoprotein involved in the regulation of inflammation and the maintenance of extracellular matrix stability, making TSG-6 essential for processes such as tissue repair, wound healing, and the development of inflammatory diseases like rheumatoid arthritis. TSG-6 functions by modulating inflammatory responses and stabilizing the extracellular matrix, which helps prevent excessive tissue damage and supports proper tissue remodeling during healing. TSG-6 interacts with hyaluronan and forms stable complexes with inter-α-inhibitor (IαI), playing a vital role in regulating the protease network and suppressing excessive inflammation. Pro-inflammatory cytokines such as TNFα and IL-1 rapidly induce TSG-6 expression, underscoring TSG-6′s pivotal role in immune responses and inflammation. TSG-6 monoclonal antibody (D-4) targets an epitope located at amino acids 135-277 at the C-terminus of human TSG-6, ensuring high specificity and robust binding for accurate detection of both precursor and mature chains. Anti-TSG-6 antibody (D-4) is reactive with the precursor and mature forms of human TSG-6 and is suitable for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TSG-6 (D-4) antibody enables researchers to gain valuable insights into inflammation mechanisms and extracellular matrix interactions, facilitating advancements in cellular biology, immunology, and inflammatory disease studies. Anti-TSG-6 antibody (D-4) serves as an indispensable tool for investigating TSG-6′s functional roles in both normal physiological processes and pathological conditions, contributing to the development of therapeutic strategies for inflammatory disorders.

The preferred TSG-6 antibody is TSG-6 Antibody (A38.1.20): sc-65886.