tsg 101 Antibody (C-2): sc-7964

tsg 101 Antibody (C-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects tsg 101 protein of mouse, rat, and human origin through applications such as western blotting, immunoprecipitation, immunofluorescence, immunohistochemistry, and enzyme-linked immunosorbent assay. tsg 101 (C-2) antibody is offered in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. tsg 101 monoclonal antibody (C-2) targets a protein that plays a crucial role in tumor suppression, encoding a stathmin binding domain protein involved in regulating cell growth and preventing malignant transformation. tsg 101 (C-2) antibody recognizes a protein essential for inhibiting cell proliferation; when tsg 101 expression is disrupted, as demonstrated in NIH/3T3 cells using antisense mRNA, cells undergo transformation leading to tumorigenicity in SL6 mice. These findings highlight tsg 101′s essential function in maintaining normal cellular behavior and potential implications in cancer research, making tsg 101 (C-2) antibody a valuable tool for studying tumorigenesis and cancer development mechanisms.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

tsg 101 Antibody (C-2) References:

1. TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes.  |  Bishop, N. and Woodman, P. 2001. J Biol Chem. 276: 11735-42. PMID: 11134028
2. Oncogenic forms of p53 inhibit p53-regulated gene expression.  |  Kern, SE., et al. 1992. Science. 256: 827-30. PMID: 1589764
3. Interaction of Tsg101 with Marburg virus VP40 depends on the PPPY motif, but not the PT/SAP motif as in the case of Ebola virus, and Tsg101 plays a critical role in the budding of Marburg virus-like particles induced by VP40, NP, and GP.  |  Urata, S., et al. 2007. J Virol. 81: 4895-9. PMID: 17301151
4. Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation.  |  Oh, KB., et al. 2007. Oncogene. 26: 5950-9. PMID: 17369844
5. The ESCRT-I subunit TSG101 controls endosome-to-cytosol release of viral RNA.  |  Luyet, PP., et al. 2008. Traffic. 9: 2279-90. PMID: 18817529
6. Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.  |  Horowitz, JM., et al. 1990. Proc Natl Acad Sci U S A. 87: 2775-9. PMID: 2181449
7. A unique N-terminal sequence in the Carnation Italian ringspot virus p36 replicase-associated protein interacts with the host cell ESCRT-I component Vps23.  |  Richardson, LG., et al. 2014. J Virol. 88: 6329-44. PMID: 24672030
8. The ESCRT-I Subunit Tsg101 Plays Novel Dual Roles in Entry and Replication of Classical Swine Fever Virus.  |  Liu, CC., et al. 2021. J Virol. 95: PMID: 33328308
9. Immunodetection of the presence or absence of full-length APC gene product in human colonic tissues.  |  Chop, AM., et al. 1995. Anticancer Res. 15: 991-7. PMID: 7645991
10. Familial pheochromocytoma associated with a novel mutation in the von Hippel-Lindau gene.  |  Gross, DJ., et al. 1996. J Clin Endocrinol Metab. 81: 147-9. PMID: 8550742
11. Frequent allelic loss at chromosome arm 3p is distinct from genetic alterations of the Von-Hippel Lindau tumor suppressor gene in head and neck cancer.  |  Waber, PG., et al. 1996. Oncogene. 12: 365-9. PMID: 8570213
12. Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells.  |  Li, L. and Cohen, SN. 1996. Cell. 85: 319-29. PMID: 8616888

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-tsg 101 Antibody (C-2) has 469 citations in a variety of scientific publications.

Primary antibodies like Anti-tsg 101 Antibody (C-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

tsg 101 Antibody (C-2) Specifications

Alternate Product Name: TSG101

Product Clone Name: C-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-138

Epitope Target: tsg 101

Epitope Species: mouse

Product Reactivity/Detection: tsg 101

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 469 citations in various scientific publications

Available Conjugates/Forms for tsg 101 Antibody (C-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin