tsg 101 Antibody (51): sc-136111

tsg 101 Antibody (51) is a mouse monoclonal IgG1 kappa light chain antibody that detects tsg 101 in mouse, rat, human, and canine samples through western blotting (WB) and immunoprecipitation (IP). anti-tsg 101 antibody (51) is available in a non-conjugated form, providing researchers with a versatile tool for studying this critical protein. tsg 101 plays a significant role in tumor suppression, as tsg 101 encodes a stathmin binding domain protein that is essential for regulating cell growth and preventing malignant transformation. tsg 101 function is particularly important because loss of tsg 101 expression can lead to uncontrolled cell proliferation, a hallmark of cancer. In experimental models, such as NIH/3T3 cells, inhibition of tsg 101 expression through antisense mRNA results in a transformed phenotype, demonstrating tsg 101′s vital role in maintaining normal cellular functions and potential as a therapeutic target in cancer research. tsg 101 (51) antibody enables researchers to gain insights into the mechanisms of tumorigenesis and explore new avenues for cancer treatment.

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tsg 101 Antibody (51) References:

1. TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes.  |  Bishop, N. and Woodman, P. 2001. J Biol Chem. 276: 11735-42. PMID: 11134028
2. Human TSG101 does not replace Saccharomyces cerevisiae VPS23 role in the quality control of plasma membrane proteins.  |  Blanco, S. and Lazo, PA. 2003. FEMS Microbiol Lett. 221: 151-4. PMID: 12725919
3. The ESCRT-I subunit TSG101 controls endosome-to-cytosol release of viral RNA.  |  Luyet, PP., et al. 2008. Traffic. 9: 2279-90. PMID: 18817529
4. Identical domains of Yarrowia lipolytica Vps23 are required for both ESCRT and Rim pathways, but the latter needs an interaction between the Vps23 UEV domain and Rim8/PalF.  |  Blanchin-Roland, S. 2011. FEMS Yeast Res. 11: 473-86. PMID: 21539706
5. Cryptococcus neoformans requires the ESCRT protein Vps23 for iron acquisition from heme, for capsule formation, and for virulence.  |  Hu, G., et al. 2013. Infect Immun. 81: 292-302. PMID: 23132495
6. A unique N-terminal sequence in the Carnation Italian ringspot virus p36 replicase-associated protein interacts with the host cell ESCRT-I component Vps23.  |  Richardson, LG., et al. 2014. J Virol. 88: 6329-44. PMID: 24672030
7. Structural Stability of the Coiled-Coil Domain of Tumor Susceptibility Gene (TSG)-101.  |  White, JT., et al. 2017. Biochemistry. 56: 4646-4655. PMID: 28776372
8. The ESCRT-I Subunit Tsg101 Plays Novel Dual Roles in Entry and Replication of Classical Swine Fever Virus.  |  Liu, CC., et al. 2021. J Virol. 95: PMID: 33328308
9. P1 promoter IGF-1 polymorphism and IGF-1, IGF-R, LSF, and TSG 101 expression profile in endometriosis.  |  Kwasniewski, W., et al. 2022. Ginekol Pol. 93: 775-786. PMID: 35072229
10. Origin of eukaryotic-like Vps23 shapes an ancient functional interplay between ESCRT and ubiquitin system in Asgard archaea.  |  Lu, Z., et al. 2024. Cell Rep. 43: 113781. PMID: 38358888

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-tsg 101 Antibody (51) has 35 citations in a variety of scientific publications.

Primary antibodies like Anti-tsg 101 Antibody (51) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

tsg 101 Antibody (51) Specifications

Alternate Product Name: TSG101

Product Clone Name: 51

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 229-319

Epitope Target: tsg 101

Epitope Species: human

Product Reactivity/Detection: tsg 101

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 35 citations in various scientific publications

Available Conjugates/Forms for tsg 101 Antibody (51): N/A

The preferred tsg 101 antibody is tsg 101 Antibody (C-2): sc-7964.