TrxR2 Antibody (F-5): sc-376868
- TrxR2 Antibody (F-5) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 261-310 mapping within an internal region of TrxR2 of mouse origin
- Anti-TrxR2 Antibody (F-5) is recommended for detection of TrxR2 of mouse and rat origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TrxR2 Antibody (F-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TrxR2 Antibody (F-5). This work is in progress.
QUICK LINKS
TrxR2 Antibody (F-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects TrxR2 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TrxR2 (F-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Thioredoxin 2 (Trx-2) is a vital redox protein localized in mitochondria, where Trx-2 plays a crucial role in maintaining cellular health by scavenging reactive oxygen species (ROS) and regulating mitochondrial apoptosis signaling pathway. Trx-2 protects cells from oxidative stress, which can lead to cell death and contribute to various diseases, including neurodegenerative disorders and cancer. TrxR2, along with TrxR1, belongs to a selenium-containing family of flavoproteins that catalyze NADPH-dependent reduction of thioredoxin and other oxidized cellular components, preventing oxidative damage. TrxR2 inhibition has been explored as a potential therapeutic strategy for treating cancer, autoimmune diseases, and infections, highlighting TrxR2′s significance in both cellular function and disease pathology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TrxR2 Antibody (F-5) References:
- Genomic organization and identification of a novel alternative splicing variant of mouse mitochondrial thioredoxin reductase (TrxR2) gene. | Miranda-Vizuete, A. and Spyrou, G. 2002. Mol Cells. 13: 488-92. PMID: 12132591
- Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferation. | Kim, MR., et al. 2003. Biochem Biophys Res Commun. 304: 119-24. PMID: 12705894
- Mitochondrial thioredoxin system: effects of TrxR2 overexpression on redox balance, cell growth, and apoptosis. | Patenaude, A., et al. 2004. J Biol Chem. 279: 27302-14. PMID: 15082714
- Single nucleotide polymorphisms in the Trx2/TXNIP and TrxR2 genes of the mitochondrial thioredoxin antioxidant system and the risk of diabetic retinopathy in patients with Type 2 diabetes mellitus. | Ramus, SM., et al. 2016. J Diabetes Complications. 30: 192-8. PMID: 26763822
- TrxR2 deficiencies promote chondrogenic differentiation and induce apoptosis of chondrocytes through mitochondrial reactive oxygen species. | Yan, J., et al. 2016. Exp Cell Res. 344: 67-75. PMID: 27107686
- Inhibition of TrxR2 suppressed NSCLC cell proliferation, metabolism and induced cell apoptosis through decreasing antioxidant activity. | Bu, L., et al. 2017. Life Sci. 178: 35-41. PMID: 28414076
- Smart mitochondrial-targeted cancer therapy: Subcellular distribution, selective TrxR2 inhibition accompany with declined antioxidant capacity. | Du, X., et al. 2019. Int J Pharm. 555: 346-355. PMID: 30500459
- TrxR2 overexpression alleviates inflammation-mediated neuronal death via reducing the oxidative stress and activating the Akt-Parkin pathway. | Gao, J., et al. 2019. Toxicol Res (Camb). 8: 641-653. PMID: 31588341
- miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2. | Bu, L., et al. 2021. Acta Biochim Biophys Sin (Shanghai). 53: 189-200. PMID: 33332541
- Mitochondrial TrxR2 regulates metabolism and protects from metabolic disease through enhanced TCA and ETC function. | Chocron, ES., et al. 2022. Commun Biol. 5: 467. PMID: 35577894
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TrxR2 Antibody (F-5) | sc-376868 | 200 µg/ml | $322.00 | |||
TrxR2 Antibody (F-5) AC | sc-376868 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TrxR2 Antibody (F-5) HRP | sc-376868 HRP | 200 µg/ml | $322.00 | |||
TrxR2 Antibody (F-5) FITC | sc-376868 FITC | 200 µg/ml | $336.00 | |||
TrxR2 Antibody (F-5) PE | sc-376868 PE | 200 µg/ml | $349.00 | |||
TrxR2 Antibody (F-5) Alexa Fluor® 488 | sc-376868 AF488 | 200 µg/ml | $364.00 | |||
TrxR2 Antibody (F-5) Alexa Fluor® 546 | sc-376868 AF546 | 200 µg/ml | $364.00 | |||
TrxR2 Antibody (F-5) Alexa Fluor® 594 | sc-376868 AF594 | 200 µg/ml | $364.00 | |||
TrxR2 Antibody (F-5) Alexa Fluor® 647 | sc-376868 AF647 | 200 µg/ml | $364.00 | |||
TrxR2 Antibody (F-5) Alexa Fluor® 680 | sc-376868 AF680 | 200 µg/ml | $364.00 | |||
TrxR2 Antibody (F-5) Alexa Fluor® 790 | sc-376868 AF790 | 200 µg/ml | $364.00 |