TRPC6 Antibody (E-7): sc-515927
- TRPC6 Antibody (E-7) is a mouse monoclonal IgG1 provided at 200 µg/ml
- specific for an epitope mapping between amino acids 834-860 within a C-terminal cytoplasmic domain of TRPC6 of human origin
- recommended for detection of TRPC6 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TRPC6 Antibody (E-7) for WB applications. These reagents are now offered in bundles with TRPC6 Antibody (E-7) (see ordering information below).
QUICK LINKS
TRPC6 Antibody (E-7) is a mouse monoclonal IgG1 antibody that detects TRPC6 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TRPC6 antibody (E-7) recognizes TRPC6, a crucial component of the transient receptor potential cation channel family, specifically involved in mediating store-operated calcium entry. This process is vital for various cellular functions, including muscle contraction, neurotransmitter release, and cell proliferation, as TRPC6 helps maintain calcium homeostasis within cells. TRPC6 is predominantly located in the placenta, spleen, lung, small intestine, and ovary, where TRPC6 plays a significant role in calcium signaling pathways essential for normal physiological processes. Notably, TRPC6 is activated by diacylglycerol (DAG) and functions as a calcium-permeable cation channel, particularly important in α1-adrenoceptor signaling. The gene encoding TRPC6 is located on chromosome 11q21-q22, and understanding TRPC6 function and regulation is critical for elucidating TRPC6′s role in various diseases, including cardiovascular and neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRPC6 Antibody (E-7) References:
- Novel Targets for Stroke Therapy: Special Focus on TRPC Channels and TRPC6. | Liu, L., et al. 2020. Front Aging Neurosci. 12: 70. PMID: 32256338
- The role of TRPC6 channel in chronic kidney disease. | Palygin, O. 2022. Am J Physiol Renal Physiol. 322: F195-F196. PMID: 35037467
- The Effects of TRPC6 Knockout in Animal Models of Kidney Disease. | Dryer, SE. and Kim, EY. 2022. Biomolecules. 12: PMID: 36421724
- An inactivating human TRPC6 channel mutation without focal segmental glomerulosclerosis. | Batool, L., et al. 2023. Cell Mol Life Sci. 80: 265. PMID: 37615749
- Podocyte Injury in Diabetic Kidney Disease in Mouse Models Involves TRPC6-mediated Calpain Activation Impairing Autophagy. | Salemkour, Y., et al. 2023. J Am Soc Nephrol. 34: 1823-1842. PMID: 37678257
- A Putative Role for TRPC6 in Immune-Mediated Kidney Injury. | 't Hart, DC., et al. 2023. Int J Mol Sci. 24: PMID: 38003608
- Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression. | Nishiyama, K., et al. 2024. Int J Mol Sci. 25: PMID: 38397074
- The roles of TRPC6 in renal tubular disorders: a narrative review. | Sheng, A., et al. 2024. Ren Fail. 46: 2376929. PMID: 39022902
- TRPC6 regulates necroptosis in myocardial ischemia/reperfusion injury via Ca2+/CaMKII signaling pathway. | Li, J., et al. 2024. Cell Signal. 122: 111344. PMID: 39134250
- Natural History and Clinicopathological Associations of TRPC6-Associated Podocytopathy. | Wooden, B., et al. 2024. J Am Soc Nephrol.. PMID: 39352759
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRPC6 Antibody (E-7) | sc-515927 | 200 µg/ml | $322.00 | |||
TRPC6 Antibody (E-7): m-IgG Fc BP-HRP Bundle | sc-538834 | 200 µg Ab; 10 µg BP | $361.00 | |||
TRPC6 Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-536513 | 200 µg Ab; 40 µg BP | $361.00 | |||
TRPC6 Antibody (E-7): m-IgG1 BP-HRP Bundle | sc-545901 | 200 µg Ab; 20 µg BP | $361.00 |