Date published: 2025-12-18

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TRPC6 Inhibitors

TRPC6 inhibitors belong to a class of chemical compounds that specifically target and modulate the activity of the Transient Receptor Potential C6 (TRPC6) ion channel. TRPC6 is a member of the TRP superfamily of cation channels, which play essential roles in various physiological processes by regulating the influx of calcium ions (Ca2+) into cells. TRPC6, in particular, is predominantly expressed in numerous tissues, including the central nervous system, cardiovascular system, and kidneys. It plays a pivotal role in cellular signaling, ion homeostasis, and cellular responses to various environmental and physiological stimuli. These inhibitors are designed to selectively bind to the TRPC6 channel, thereby blocking or reducing its activity. The exact mechanism of inhibition can vary among different compounds, but the primary goal is to prevent the aberrant or excessive influx of calcium ions into cells. Dysregulated TRPC6 activity has been implicated in various pathological conditions, such as neurodegenerative diseases, cardiovascular disorders, and kidney diseases. By inhibiting TRPC6, these compounds aim to restore the proper balance of calcium ions within cells, potentially mitigating the downstream cellular dysfunction associated with TRPC6 hyperactivity.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SK&F 96365

130495-35-1sc-201475
sc-201475B
sc-201475A
sc-201475C
5 mg
10 mg
25 mg
50 mg
$101.00
$155.00
$389.00
$643.00
2
(1)

SKF-96365 is known to act as a non-selective inhibitor of TRP channels, and it has been shown to effectively block TRPC6 channel activity. This blockade could potentially lead to reduced expression of TRPC6.

2-APB

524-95-8sc-201487
sc-201487A
20 mg
100 mg
$27.00
$52.00
37
(1)

2-APB is a widely used modulator of ion channels, including TRP channels. It has been reported to inhibit TRPC6 channels, potentially impacting their expression levels in cells.

Pyr3

1160514-60-2sc-301624
sc-301624A
sc-301624B
5 mg
10 mg
25 mg
$148.00
$255.00
$510.00
(0)

Pyr3 is identified as a potent and selective inhibitor of TRPC3 and TRPC6 channels. By selectively blocking TRPC6 channels, Pyr3 might contribute to a decrease in TRPC6 expression.

SAR7334

1333210-07-3sc-507445
10 mg
$510.00
(0)

SAR7334 is a highly selective inhibitor of TRPC6 channels. It is capable of inhibiting TRPC6 activity, which could result in a downregulation of TRPC6 protein levels.

CRAC Channel Inhibitor, BTP2

223499-30-7sc-221441
5 mg
$185.00
9
(1)

BTP2 is known to inhibit a range of ion channels, including TRPC channels. Its inhibition of TRPC6 might lead to reduced TRPC6 protein expression in cells.

Lanthanum

7439-91-0sc-250228
25 g
$180.00
(0)

La3+ ions have been reported to block various ion channels, including TRPC6. This blockade could potentially contribute to decreased expression of TRPC6 protein.

4-Methyl-2-(1-piperidinyl)-quinoline

5465-86-1sc-483337
25 mg
$430.00
(0)

ML204 is identified as a selective inhibitor of TRPC4 and TRPC6 channels. By inhibiting TRPC6, it might play a role in reducing TRPC6 protein levels in cells.

Flufenamic acid

530-78-9sc-205699
sc-205699A
sc-205699B
sc-205699C
10 g
50 g
100 g
250 g
$26.00
$77.00
$151.00
$303.00
1
(1)

FFA is a blocker of non-selective cation channels and has been shown to inhibit TRPC6 channels. This inhibition might lead to a decrease in TRPC6 protein expression.