TRPC3 Antibody (C-5): sc-514670

TRPC3 Antibody (C-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects TRPC3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRPC3 (C-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The transient receptor potential cation (TRPC) channels, to which TRPC3 belongs, are integral to the regulation of calcium homeostasis within cells, playing a crucial role in store-operated calcium entry. This process is vital for numerous cellular functions, including muscle contraction, neurotransmitter release, and gene expression. TRPC3 is predominantly expressed in the brain, where TRPC3 contributes to neuronal signaling and plasticity. The activation of TRPC3 is intricately linked to the interaction between inositol 1,4,5-trisphosphate receptors and the channel itself, facilitating calcium influx in response to various stimuli. Additionally, TRPC3 can be activated by diacylglycerol independently of protein kinase C, highlighting TRPC3′s importance in diverse signaling pathways. Understanding the function and regulation of TRPC3 is essential for elucidating TRPC3′s role in physiological processes and potential implications in pathological conditions.

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TRPC3 Antibody (C-5) References:

1. From worm to man: three subfamilies of TRP channels.  |  Harteneck, C., et al. 2000. Trends Neurosci. 23: 159-66. PMID: 10717675
2. Transient receptor potential channels as molecular substrates of receptor-mediated cation entry.  |  Hofmann, T., et al. 2000. J Mol Med (Berl). 78: 14-25. PMID: 10759026
3. The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel.  |  Inoue, R., et al. 2001. Circ Res. 88: 325-32. PMID: 11179201
4. Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets.  |  Rosado, JA. and Sage, SO. 2001. Biochem J. 356: 191-8. PMID: 11336651
5. TRPC3 channels are necessary for brain-derived neurotrophic factor to activate a nonselective cationic current and to induce dendritic spine formation.  |  Amaral, MD. and Pozzo-Miller, L. 2007. J Neurosci. 27: 5179-89. PMID: 17494704
6. Monocytes from spontaneously hypertensive rats show increased store-operated and second messenger-operated calcium influx mediated by transient receptor potential canonical Type 3 channels.  |  Liu, DY., et al. 2007. Am J Hypertens. 20: 1111-8. PMID: 17903696
7. TRPC1, a human homolog of a Drosophila store-operated channel.  |  Wes, PD., et al. 1995. Proc Natl Acad Sci U S A. 92: 9652-6. PMID: 7568191
8. Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion.  |  Zitt, C., et al. 1996. Neuron. 16: 1189-96. PMID: 8663995
9. A novel capacitative calcium entry channel expressed in excitable cells.  |  Philipp, S., et al. 1998. EMBO J. 17: 4274-82. PMID: 9687496
10. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.  |  Hofmann, T., et al. 1999. Nature. 397: 259-63. PMID: 9930701
11. Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate.  |  Lemonnier, L., et al. 2008. Cell Calcium. 43: 506-14. PMID: 17942152

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRPC3 Antibody (C-5) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-TRPC3 Antibody (C-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRPC3 Antibody (C-5) Specifications

Alternate Product Name: TRPC3

Product Clone Name: C-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-100

Epitope Target: TRPC3

Epitope Species: human

Product Reactivity/Detection: TRPC3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for TRPC3 Antibody (C-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin