TRPC1 Antibody (E-6): sc-133076

TRPC1 Antibody (E-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects TRPC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TRPC1 (E-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The transient receptor potential cation (TRPC) channels, to which TRPC1 belongs, are integral to the regulation of calcium homeostasis in cells, playing a crucial role in store-operated calcium entry (SOCE). This process is vital for various physiological functions, including muscle contraction, neurotransmitter release, and cellular signaling. TRPC1, a 793 amino acid protein, is predominantly expressed in the fetal and adult brain, as well as in the adult heart, testis, and ovary, where TRPC1 contributes to the formation of capacitative calcium entry complexes. The interaction between inositol 1,4,5-trisphosphate receptors and TRPC1 is essential for the activation of store-mediated calcium entry, highlighting TRPC1′s importance in cellular responses to calcium depletion. Anti-TRPC1 antibody (E-6) enables researchers to gain insights into the mechanisms of calcium signaling and its implications in various biological processes and diseases.

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TRPC1 Antibody (E-6) References:

1. From worm to man: three subfamilies of TRP channels.  |  Harteneck, C., et al. 2000. Trends Neurosci. 23: 159-66. PMID: 10717675
2. Transient receptor potential channels as molecular substrates of receptor-mediated cation entry.  |  Hofmann, T., et al. 2000. J Mol Med (Berl). 78: 14-25. PMID: 10759026
3. Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets.  |  Rosado, JA. and Sage, SO. 2001. Biochem J. 356: 191-8. PMID: 11336651
4. TRPC1 store-operated cationic channel subunit.  |  Beech, DJ., et al. 2003. Cell Calcium. 33: 433-40. PMID: 12765688
5. TRPC1 and ORAI1 channels in colon cancer.  |  Villalobos, C., et al. 2019. Cell Calcium. 81: 59-66. PMID: 31203007
6. TRPC1 as a negative regulator for TRPC4 and TRPC5 channels.  |  Kim, J., et al. 2019. Pflugers Arch. 471: 1045-1053. PMID: 31222490
7. TRPC1 contributes to endotoxemia-induced myocardial dysfunction via mediating myocardial apoptosis and autophagy.  |  Tian, W., et al. 2022. Pharmacol Res. 181: 106262. PMID: 35598715
8. Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel.  |  Won, J., et al. 2024. Nat Struct Mol Biol.. PMID: 39478185
9. TRPC1, a human homolog of a Drosophila store-operated channel.  |  Wes, PD., et al. 1995. Proc Natl Acad Sci U S A. 92: 9652-6. PMID: 7568191
10. Molecular cloning of a widely expressed human homologue for the Drosophila trp gene.  |  Zhu, X., et al. 1995. FEBS Lett. 373: 193-8. PMID: 7589464
11. Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion.  |  Zitt, C., et al. 1996. Neuron. 16: 1189-96. PMID: 8663995
12. A novel capacitative calcium entry channel expressed in excitable cells.  |  Philipp, S., et al. 1998. EMBO J. 17: 4274-82. PMID: 9687496

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRPC1 Antibody (E-6) has 45 citations in a variety of scientific publications.

Primary antibodies like Anti-TRPC1 Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRPC1 Antibody (E-6) Specifications

Alternate Product Name: TRPC1

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 689-793

Epitope Target: TRPC1

Epitope Species: human

Product Reactivity/Detection: TRPC1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 45 citations in various scientific publications

Available Conjugates/Forms for TRPC1 Antibody (E-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin