Troponin T-SS Antibody (A-8): sc-271673

Troponin T-SS Antibody (A-8) is a mouse monoclonal IgG2a antibody that detects Troponin T-SS in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Troponin T-SS plays a crucial role in muscle contraction by linking the troponin complex to the actin filaments, thereby facilitating the interaction between actin and myosin in muscle cells. This interaction is essential for the regulation of muscle contraction, particularly in slow skeletal muscle, where Troponin T-SS is specifically expressed in three isoforms due to alternative splicing. The presence of these isoforms allows for fine-tuning of muscle contraction dynamics, which is vital for maintaining proper muscle function and response to physiological demands. Defects in the gene encoding Troponin T-SS can lead to serious conditions such as nemaline myopathy type 5, underscoring the importance of this protein in muscle health. Anti-Troponin T-SS antibody (A-8) is an invaluable tool for researchers studying muscle physiology and related disorders, providing reliable detection and characterization of this critical protein.

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Troponin T-SS Antibody (A-8) References:

1. Close physical linkage of human troponin genes: organization, sequence, and expression of the locus encoding cardiac troponin I and slow skeletal troponin T.  |  Barton, PJ., et al. 1999. Genomics. 57: 102-9. PMID: 10191089
2. RNA expression of cardiac troponin T isoforms in diseased human skeletal muscle.  |  Ricchiuti, V. and Apple, FS. 1999. Clin Chem. 45: 2129-35. PMID: 10585344
3. Assignment of the human slow skeletal troponin T gene to 19q13.4 using somatic cell hybrids and fluorescence in situ hybridization analysis.  |  Samson, F., et al. 1992. Genomics. 13: 1374-5. PMID: 1505979
4. The slow skeletal muscle troponin T gene is expressed in developing and diseased human heart.  |  Barton, PJ., et al. 2004. Mol Cell Biochem. 263: 91-7. PMID: 15524170
5. Expression and functional properties of four slow skeletal troponin T isoforms in rat muscles.  |  Kischel, P., et al. 2005. Am J Physiol Cell Physiol. 289: C437-43. PMID: 15788488
6. Identification and analysis of teleost slow muscle troponin T (sTnT) and intronless TnT genes.  |  Campinho, MA., et al. 2005. Gene. 361: 67-79. PMID: 16168583
7. The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation.  |  Pinto, JR., et al. 2012. J Biol Chem. 287: 37362-70. PMID: 22977240
8. The slow skeletal muscle troponin T gene is expressed in developing and diseased human heart.  |  Barton, PJ., et al. 2004. Mol Cell Biochem. 263: 91-7. PMID: 27520668
9. Alternative splicing generates variants in important functional domains of human slow skeletal troponin T.  |  Gahlmann, R., et al. 1987. J Biol Chem. 262: 16122-6. PMID: 2824479
10. A new human slow skeletal troponin T (TnTs) mRNA isoform derived from alternative splicing of a single gene.  |  Samson, F., et al. 1994. Biochem Biophys Res Commun. 199: 841-7. PMID: 8135831

The preferred Troponin T-SS antibody is Troponin T-SS Antibody (A-9): sc-365014.