Trk C Antibody (7H6): sc-517245
- Trk C Antibody (7H6) is a mouse monoclonal IgG1 κ Trk C antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 32-429 of Trk C of human origin
- Trk C Antibody (7H6) is recommended for detection of Trk C of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Trk C Antibody (7H6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Trk C Antibody (7H6) for WB and IHC(P) applications. These reagents are now offered in bundles with Trk C Antibody (7H6) (see ordering information below).
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Trk C Antibody (7H6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Trk C protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Trk C antibody (7H6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Trk C protein, a member of the tropomyosin receptor kinase family, plays a crucial role in the nervous system as a receptor for neurotrophin-3 (NT-3), which is essential for the survival and differentiation of neurons. Trk C is predominantly expressed in nervous tissue, and activation leads to phosphorylation of tyrosine residues, triggering downstream signaling pathways that promote neuronal growth and survival. Notably, Trk C undergoes alternative splicing, resulting in four isoforms, each with distinct structural features that may influence functional properties and interactions with NT-3. Understanding specific interactions and signaling mechanisms of Trk C is vital for elucidating its role in neurodevelopment and potential implications in neurodegenerative diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Trk C Antibody (7H6) References:
- Neurotrophin receptors (Trk A, Trk B, and Trk C) in the developing and adult human retina. | Nag, TC. and Wadhwa, S. 1999. Brain Res Dev Brain Res. 117: 179-89. PMID: 10567736
- Trk C signaling is required for retinal progenitor cell proliferation. | Das, I., et al. 2000. J Neurosci. 20: 2887-95. PMID: 10751441
- Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo. | Lin, MI., et al. 2000. Dev Biol. 226: 180-91. PMID: 11023679
- Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease. | Savaskan, E., et al. 2000. Eur Neurol. 44: 172-80. PMID: 11053967
- The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. | Cordon-Cardo, C., et al. 1991. Cell. 66: 173-83. PMID: 1649007
- The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. | Klein, R., et al. 1991. Cell. 66: 395-403. PMID: 1649702
- Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. | Kaplan, DR., et al. 1991. Nature. 350: 158-60. PMID: 1706478
- The trk proto-oncogene encodes a receptor for nerve growth factor. | Klein, R., et al. 1991. Cell. 65: 189-97. PMID: 1849459
- High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. | Hempstead, BL., et al. 1991. Nature. 350: 678-83. PMID: 1850821
- Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system. | Klein, R., et al. 1990. Development. 109: 845-50. PMID: 2171894
- trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. | Klein, R., et al. 1989. EMBO J. 8: 3701-9. PMID: 2555172
- Coexpression of mRNA for the full-length neurotrophin receptor trk-C and trk-A in favourable neuroblastoma. | Svensson, T., et al. 1997. Eur J Cancer. 33: 2058-63. PMID: 9580079
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Trk C Antibody (7H6) | sc-517245 | 200 µg/ml | $322.00 | |||
Trk C Antibody (7H6): m-IgG Fc BP-HRP Bundle | sc-531568 | 200 µg Ab; 10 µg BP | $361.00 | |||
Trk C Antibody (7H6): m-IgGκ BP-HRP Bundle | sc-525296 | 200 µg Ab, 40 µg BP | $361.00 | |||
Trk C Antibody (7H6): m-IgG1 BP-HRP Bundle | sc-544628 | 200 µg Ab; 20 µg BP | $361.00 | |||
Trk C Antibody (7H6) AC | sc-517245 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Trk C Antibody (7H6) HRP | sc-517245 HRP | 200 µg/ml | $322.00 | |||
Trk C Antibody (7H6) FITC | sc-517245 FITC | 200 µg/ml | $336.00 | |||
Trk C Antibody (7H6) PE | sc-517245 PE | 200 µg/ml | $349.00 | |||
Trk C Antibody (7H6) Alexa Fluor® 488 | sc-517245 AF488 | 200 µg/ml | $364.00 | |||
Trk C Antibody (7H6) Alexa Fluor® 546 | sc-517245 AF546 | 200 µg/ml | $364.00 | |||
Trk C Antibody (7H6) Alexa Fluor® 594 | sc-517245 AF594 | 200 µg/ml | $364.00 | |||
Trk C Antibody (7H6) Alexa Fluor® 647 | sc-517245 AF647 | 200 µg/ml | $364.00 | |||
Trk C Antibody (7H6) Alexa Fluor® 680 | sc-517245 AF680 | 200 µg/ml | $364.00 | |||
Trk C Antibody (7H6) Alexa Fluor® 790 | sc-517245 AF790 | 200 µg/ml | $364.00 |