TRIP6 Antibody (F-8): sc-166310
- TRIP6 Antibody (F-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 124-156 within an internal region of TRIP6 of mouse origin
- Anti-TRIP6 Antibody (F-8) is recommended for detection of TRIP6 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TRIP6 Antibody (F-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TRIP6 Antibody (F-8) for WB applications. These reagents are now offered in bundles with TRIP6 Antibody (F-8) (see ordering information below).
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TRIP6 Antibody (F-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects TRIP6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRIP6 monoclonal antibody (F-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TRIP6, also known as thyroid receptor interacting protein 6, plays a critical role in cellular signaling pathways by interacting with various proteins involved in inflammation and immune responses. Notably, TRIP6 interacts with receptor-interacting protein 2 (RIP2) through LIM domains in a manner dependent on tumor necrosis factor (TNF) or interleukin-1 (IL-1). This interaction facilitates the activation of nuclear factor kappa B (NFkappaB), a key transcription factor involved in regulating immune responses and inflammation. TRIP6 enhances the activation of extracellular signal-regulated kinase (ERK) in response to RIP2 and Nod1, further underscoring TRIP6′s importance in mediating cellular responses to inflammatory signals. TRIP6 expression is predominantly found in the kidney, liver, and lung, highlighting TRIP6′s potential role in organ-specific signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRIP6 Antibody (F-8) References:
- TRIP6: an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity. | Lin, VT. and Lin, FT. 2011. Cell Signal. 23: 1691-7. PMID: 21689746
- Defining the role of TRIP6 in cell physiology and cancer. | Willier, S., et al. 2011. Biol Cell. 103: 573-91. PMID: 22054418
- TRIP6 promotes cell proliferation in hepatocellular carcinoma via suppression of FOXO3a. | Zhao, W., et al. 2017. Biochem Biophys Res Commun. 494: 594-601. PMID: 29080747
- TRIP6 promotes tumorigenic capability through regulating FOXC1 in hepatocellular carcinoma. | Wang, F., et al. 2020. Pathol Res Pract. 216: 152850. PMID: 32046874
- TRIP6 accelerates the proliferation and invasion of cervical cancer by upregulating oncogenic YAP signaling. | Yang, F., et al. 2020. Exp Cell Res. 396: 112248. PMID: 32853630
- TRIP6 is required for tension at adherens junctions. | Venkatramanan, S., et al. 2021. J Cell Sci. 134: PMID: 33558314
- TRIP6 promotes inflammatory damage via the activation of TRAF6 signaling in a murine model of DSS-induced colitis. | Yang, Y., et al. 2022. J Inflamm (Lond). 19: 1. PMID: 34983535
- TRIP6 disrupts tight junctions to promote metastasis and drug resistance and is a therapeutic target in colorectal cancer. | Gou, H., et al. 2023. Cancer Lett. 578: 216438. PMID: 37827326
- TRIP6 a potential diagnostic marker for colorectal cancer with glycolysis and immune infiltration association. | Liu, XS., et al. 2024. Sci Rep. 14: 4042. PMID: 38369589
- Construction of an immune predictive model and identification of TRIP6 as a prognostic marker and therapeutic target of CRC by integration of single-cell and bulk RNA-seq data. | Liu, W., et al. 2024. Cancer Immunol Immunother. 73: 69. PMID: 38430268
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRIP6 Antibody (F-8) | sc-166310 | 200 µg/ml | $316.00 | |||
TRIP6 Antibody (F-8): m-IgG Fc BP-HRP Bundle | sc-528942 | 200 µg Ab; 10 µg BP | $354.00 | |||
TRIP6 Antibody (F-8): m-IgGκ BP-HRP Bundle | sc-521564 | 200 µg Ab, 40 µg BP | $354.00 | |||
TRIP6 Antibody (F-8): m-IgG1 BP-HRP Bundle | sc-543227 | 200 µg Ab; 20 µg BP | $354.00 | |||
TRIP6 Antibody (F-8) AC | sc-166310 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TRIP6 Antibody (F-8) HRP | sc-166310 HRP | 200 µg/ml | $316.00 | |||
TRIP6 Antibody (F-8) FITC | sc-166310 FITC | 200 µg/ml | $330.00 | |||
TRIP6 Antibody (F-8) PE | sc-166310 PE | 200 µg/ml | $343.00 | |||
TRIP6 Antibody (F-8) Alexa Fluor® 488 | sc-166310 AF488 | 200 µg/ml | $357.00 | |||
TRIP6 Antibody (F-8) Alexa Fluor® 546 | sc-166310 AF546 | 200 µg/ml | $357.00 | |||
TRIP6 Antibody (F-8) Alexa Fluor® 594 | sc-166310 AF594 | 200 µg/ml | $357.00 | |||
TRIP6 Antibody (F-8) Alexa Fluor® 647 | sc-166310 AF647 | 200 µg/ml | $357.00 | |||
TRIP6 Antibody (F-8) Alexa Fluor® 680 | sc-166310 AF680 | 200 µg/ml | $357.00 | |||
TRIP6 Antibody (F-8) Alexa Fluor® 790 | sc-166310 AF790 | 200 µg/ml | $357.00 | |||
TRIP6 (F-8) Neutralizing Peptide | sc-166310 P | 100 µg/0.5 ml | $68.00 |