TRIP6 Antibody (F-5): sc-365122

TRIP6 Antibody (F-5) is a mouse monoclonal IgG3 kappa light chain antibody that detects TRIP6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-TRIP6 antibody (F-5) is available as the non-conjugated form. Thyroid receptor interacting protein 6 (TRIP6) is a Zyxin-related protein that plays a critical role in cellular signaling and cytoskeletal organization. TRIP6 is primarily localized to focal adhesion plaques and actin filament bundles, which are essential for maintaining cell shape and facilitating communication between the extracellular matrix and the cytoskeleton. This localization is crucial for processes such as cell migration, adhesion, and response to mechanical stress. TRIP6 interacts with various proteins, including receptor-interacting protein 2 (RIP2) and TRAF2, which are integral to TNF signaling pathways. TRIP6′s ability to modulate NFkappaB activation in response to TNF, IL-1, TLR2, or Nod1 highlights its importance in inflammatory responses and cellular signaling. Additionally, TRIP6 enhances ERK activation mediated by RIP2 and Nod1, further underscoring its role in regulating key signaling pathways.

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TRIP6 Antibody (F-5) References:

1. LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor.  |  Zhao, MK., et al. 1999. Gene Expr. 8: 207-17. PMID: 10794523
2. LIM domain protein Trip6 has a conserved nuclear export signal, nuclear targeting sequences, and multiple transactivation domains.  |  Wang, Y. and Gilmore, TD. 2001. Biochim Biophys Acta. 1538: 260-72. PMID: 11336797
3. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.  |  Xu, J., et al. 2004. J Biol Chem. 279: 10459-68. PMID: 14688263
4. TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways.  |  Li, L., et al. 2005. J Cell Sci. 118: 555-63. PMID: 15657077
5. c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration.  |  Lai, YJ., et al. 2005. Mol Cell Biol. 25: 5859-68. PMID: 15988003
6. The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins.  |  Petit, MM., et al. 2005. FEBS Lett. 579: 5061-8. PMID: 16137684
7. [Down-regulation of TRIP6 expression induces actin cytoskeleton rearrangements in human carcinoma cell lines].  |  Gur'ianova, OA., et al. 2005. Mol Biol (Mosk). 39: 905-9. PMID: 16240724
8. TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase.  |  Solaz-Fuster, MC., et al. 2006. Cell Signal. 18: 1702-12. PMID: 16624523
9. TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness.  |  Chastre, E., et al. 2009. FASEB J. 23: 916-28. PMID: 19017743
10. Characterization of TRIP6-dependent nasopharyngeal cancer cell migration.  |  Fei, J., et al. 2013. Tumour Biol. 34: 2329-35. PMID: 23576104
11. The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes.  |  Seborova, K., et al. 2021. Int J Mol Sci. 23: PMID: 35008510
12. TRIM55 Promotes Proliferation of Hepatocellular Carcinoma Through Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling.  |  Lu, X., et al. 2023. J Hepatocell Carcinoma. 10: 1281-1293. PMID: 37554583

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRIP6 Antibody (F-5) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-TRIP6 Antibody (F-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRIP6 Antibody (F-5) Specifications

Alternate Product Name: TRIP6

Product Clone Name: F-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 57-83

Epitope Target: TRIP6

Epitope Species: human

Product Reactivity/Detection: TRIP6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for TRIP6 Antibody (F-5): P: Blocking Peptide