TRIM37 Antibody (B-11): sc-514828

TRIM37 Antibody (B-11) is a mouse monoclonal IgG1 antibody that detects TRIM37 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRIM37 is a crucial protein that localizes to peroxisomes and features a tripartite motif (TRIM) along with a tumor necrosis factor-receptor associated factor (TRAF) domain, which are essential for its role as an E3 ubiquitin ligase. This function is particularly important as TRIM37 regulates protein degradation and cellular homeostasis, impacting various cellular processes including cell cycle progression and apoptosis. TRIM37 expression is notably low in tissues such as the liver, ovary, heart, lung, skeletal muscle, and kidney, while showing high expression in the testis and brain, indicating potential involvement in reproductive and neurological functions. Mutations in TRIM37 are linked to Mulibrey nanism, an autosomal recessive disorder characterized by distinct craniofacial features, heart disease, and other serious health issues, underscoring TRIM37′s significance in developmental biology and disease pathology. Anti-TRIM37 antibody (B-11) is an invaluable tool for researchers studying the intricate roles of TRIM37 in various biological contexts.

The preferred TRIM37 antibody is TRIM37 Antibody (C-6): sc-515044.