TRIM37 Antibody (C-6): sc-515044
- TRIM37 Antibody (C-6) is a mouse monoclonal IgG2a κ TRIM37 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 152-451 mapping within an internal region of TRIM37 of human origin
- TRIM37 Antibody (C-6) is recommended for detection of TRIM37 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TRIM37 Antibody (C-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for TRIM37 Antibody (C-6) for WB applications. These reagents are now offered in bundles with TRIM37 Antibody (C-6) (see ordering information below).
TRIM37 Antibody (C-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects TRIM37 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRIM37 Antibody (C-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TRIM37, also known as KIAA0898, is crucial for cellular function as TRIM37 localizes to peroxisomes and plays a significant role in protein ubiquitination, acting as an E3 ubiquitin ligase. This function is vital for regulating protein degradation and maintaining cellular homeostasis, which can impact various biological processes, including cell cycle progression and response to stress. TRIM37 is highly conserved across species, with low expression levels observed in the liver, ovary, heart, lung, skeletal muscle, and kidney, while TRIM37 is highly expressed in the testis and brain. Notably, mutations in TRIM37 are linked to Mulibrey nanism, an autosomal recessive disorder characterized by distinct craniofacial features, heart disease, and impaired sexual maturation, underscoring TRIM37′s importance in developmental processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRIM37 Antibody (C-6) References:
- Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism. | Avela, K., et al. 2000. Nat Genet. 25: 298-301. PMID: 10888877
- The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder. | Kallijärvi, J., et al. 2002. Am J Hum Genet. 70: 1215-28. PMID: 11938494
- A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity. | Jagiello, P., et al. 2003. Hum Mutat. 21: 630-5. PMID: 12754710
- Mulibrey nanism: clinical features and diagnostic criteria. | Karlberg, N., et al. 2004. J Med Genet. 41: 92-8. PMID: 14757854
- Novel mutations in the TRIM37 gene in Mulibrey Nanism. | Hämäläinen, RH., et al. 2004. Hum Mutat. 23: 522. PMID: 15108285
- Bioreductive fluorescent markers for hypoxic cells: a study of 2-nitroimidazoles with 1-substituents containing fluorescent, bridgehead-nitrogen, bicyclic systems. | Hodgkiss, RJ., et al. 1992. J Med Chem. 35: 1920-6. PMID: 1588568
- Insulin resistance syndrome in subjects with mutated RING finger protein TRIM37. | Karlberg, N., et al. 2005. Diabetes. 54: 3577-81. PMID: 16306379
- Characterisation of the mulibrey nanism-associated TRIM37 gene: transcription initiation, promoter region and alternative splicing. | Hämäläinen, RH., et al. 2006. Gene. 366: 180-8. PMID: 16310976
- Tissue expression of the mulibrey nanism-associated Trim37 protein in embryonic and adult mouse tissues. | Kallijärvi, J., et al. 2006. Histochem Cell Biol. 126: 325-34. PMID: 16514549
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRIM37 Antibody (C-6) | sc-515044 | 200 µg/ml | $322.00 | |||
TRIM37 Antibody (C-6): m-IgG Fc BP-HRP Bundle | sc-526413 | 200 µg Ab; 10 µg BP | $361.00 | |||
TRIM37 Antibody (C-6): m-IgG2a BP-HRP Bundle | sc-546633 | 200 µg Ab; 10 µg BP | $361.00 | |||
TRIM37 Antibody (C-6) AC | sc-515044 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TRIM37 Antibody (C-6) HRP | sc-515044 HRP | 200 µg/ml | $322.00 | |||
TRIM37 Antibody (C-6) FITC | sc-515044 FITC | 200 µg/ml | $336.00 | |||
TRIM37 Antibody (C-6) PE | sc-515044 PE | 200 µg/ml | $349.00 | |||
TRIM37 Antibody (C-6) Alexa Fluor® 488 | sc-515044 AF488 | 200 µg/ml | $364.00 | |||
TRIM37 Antibody (C-6) Alexa Fluor® 546 | sc-515044 AF546 | 200 µg/ml | $364.00 | |||
TRIM37 Antibody (C-6) Alexa Fluor® 594 | sc-515044 AF594 | 200 µg/ml | $364.00 | |||
TRIM37 Antibody (C-6) Alexa Fluor® 647 | sc-515044 AF647 | 200 µg/ml | $364.00 | |||
TRIM37 Antibody (C-6) Alexa Fluor® 680 | sc-515044 AF680 | 200 µg/ml | $364.00 | |||
TRIM37 Antibody (C-6) Alexa Fluor® 790 | sc-515044 AF790 | 200 µg/ml | $364.00 |