TRF2 Antibody (9F10): sc-47693

TRF2 Antibody (9F10) is a mouse monoclonal IgG1 kappa light chain antibody that detects TRF2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TRF2 (9F10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TRF2, also known as Telomeric Repeat Binding Factor 2, plays a crucial role in maintaining telomere integrity by binding to the telomeric DNA sequence 5′-TTAGGG-3′, thereby preventing chromosome ends from fusing together. This function is vital for cellular stability, as telomeres protect chromosome ends from degradation and fusion, which can lead to genomic instability and contribute to cancer progression. TRF2 works in concert with TRF1, another telomere-binding protein, to regulate telomerase activity and limit telomere elongation, ensuring cells do not undergo uncontrolled proliferation. Dynamic localization of TRF2 within cells, particularly movement from the nucleolus during different phases of the cell cycle, underscores importance in cellular processes such as replication and division. Understanding TRF2 function and regulation is essential for elucidating mechanisms of cellular aging and tumorigenesis, making anti-TRF2 antibody (9F10) a valuable tool for researchers studying these critical biological processes.

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TRF2 Antibody (9F10) References:

1. Immunohistochemical telomeric-repeat binding factor-1 expression in gastrointestinal tumors.  |  Aragona, M., et al. 2000. Oncol Rep. 7: 987-90. PMID: 10948327
2. Expression of telomeric repeat binding factor 1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas.  |  Matsutani, N., et al. 2001. Int J Oncol. 19: 507-12. PMID: 11494028
3. Telomerase reverse transcriptase and telomeric-repeat binding factor protein 1 as regulators of telomerase activity in pancreatic cancer cells.  |  Yajima, T., et al. 2001. Br J Cancer. 85: 752-7. PMID: 11531263
4. The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182).  |  Seimiya, H. and Smith, S. 2002. J Biol Chem. 277: 14116-26. PMID: 11854288
5. Expression of mRNAs for telomeric repeat binding factor (TRF)-1 and TRF2 in atypical adenomatous hyperplasia and adenocarcinoma of the lung.  |  Nakanishi, K., et al. 2003. Clin Cancer Res. 9: 1105-11. PMID: 12631614
6. Expression of the telomeric repeat binding factor gene NgTRF1 is closely coordinated with the cell division program in tobacco BY-2 suspension culture cells.  |  Yang, SW., et al. 2003. J Biol Chem. 278: 21395-407. PMID: 12646586
7. Nucleolar localization of the human telomeric repeat binding factor 2 (TRF2).  |  Zhang, S., et al. 2004. J Cell Sci. 117: 3935-45. PMID: 15265990
8. Expression of telomeric repeat binding factor-1 in astroglial brain tumors.  |  La Torre, D., et al. 2005. Neurosurgery. 56: 802-10. PMID: 15792519
9. The telomeric protein TERF2/TRF2 impairs HMGB1-driven autophagy.  |  Iachettini, S., et al. 2023. Autophagy. 19: 1479-1490. PMID: 36310382
10. MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer.  |  Dinami, R., et al. 2023. EMBO Mol Med. 15: e16033. PMID: 36426578
11. DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres.  |  Myler, LR., et al. 2023. Nat Struct Mol Biol. 30: 1346-1356. PMID: 37653239
12. Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells.  |  Sobinoff, AP., et al. 2023. Cell Chem Biol. 30: 1652-1665.e6. PMID: 38065101

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TRF2 Antibody (9F10) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-TRF2 Antibody (9F10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TRF2 Antibody (9F10) Specifications

Alternate Product Name: TERF2

Product Clone Name: 9F10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: TRF2

Epitope Species: human

Product Reactivity/Detection: TRF2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for TRF2 Antibody (9F10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, L: Azide-Free, PE: Phycoerythrin, X: TransCruz Reagent