TRB-3 Antibody (G-10): sc-271572
- TRB-3 Antibody (G-10) is a mouse monoclonal IgG2b κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 1-140 mapping at the N-terminus of TRB-3 of human origin
- recommended for detection of TRB-3 of human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TRB-3 Antibody (G-10) for WB applications. These reagents are now offered in bundles with TRB-3 Antibody (G-10) (see ordering information below).
TRB-3 Antibody (G-10) is a mouse monoclonal IgG2b antibody that detects TRB-3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRB-3, also known as tribbles 3 or neuronal cell death-inducible protein kinase, plays a critical role in disrupting insulin signaling by directly binding to Akt kinases, thereby inhibiting their activation. This mechanism is particularly important as TRB-3 contributes to insulin resistance, a key factor in the development of type II diabetes. TRB-3 is predominantly expressed in the liver, pancreas, peripheral blood leukocytes, and bone marrow, highlighting TRB-3′s significance in metabolic regulation and cellular signaling pathways. In diabetic models, elevated levels of TRB-3 RNA and protein have been observed, indicating TRB-3′s potential as a biomarker for insulin resistance. TRB-3′s ability to interact with other proteins, such as ATF4, further underscores TRB-3′s role in modulating transcriptional activities and MAP kinase activation, making anti-TRB-3 antibody (G-10) an essential tool for researchers studying metabolic disorders and insulin signaling pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRB-3 Antibody (G-10) | sc-271572 | 200 µg/ml | $322.00 | |||
TRB-3 Antibody (G-10): m-IgGκ BP-HRP Bundle | sc-535001 | 200 µg Ab; 40 µg BP | $361.00 | |||
TRB-3 Antibody (G-10): m-IgG2b BP-HRP Bundle | sc-549328 | 200 µg Ab; 10 µg BP | $361.00 |