Transaldolase Antibody (H-4): sc-166230

Transaldolase Antibody (H-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Transaldolase (TALDO) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-TALDO antibody (H-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TALDO plays a crucial role in cellular metabolism, particularly in the nonoxidative phase of the pentose phosphate pathway, where TALDO is essential for generating NADPH and ribose-5-phosphate. These metabolites are vital for nucleic acid and lipid biosynthesis, which are critical for proper cell growth, differentiation, and survival. TALDO′s importance extends to maintaining mitochondrial transmembrane potential, which is necessary for energy production and cellular function. Notably, TALDO deficiencies have been linked to male infertility, as these can lead to structural and functional impairments in spermatozoa. Furthermore, mutations in the gene encoding TALDO are associated with serious health conditions, including multiple sclerosis, hepatosplenomegaly, and skin telangiectases, highlighting TALDO′s significance in both metabolic processes and disease pathology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Transaldolase Antibody (H-4) References:

1. The three-dimensional structure of human transaldolase.  |  Thorell, S., et al. 2000. FEBS Lett. 475: 205-8. PMID: 10869557
2. Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway.  |  Verhoeven, NM., et al. 2001. Am J Hum Genet. 68: 1086-92. PMID: 11283793
3. A newborn with severe liver failure, cardiomyopathy and transaldolase deficiency.  |  Verhoeven, NM., et al. 2005. J Inherit Metab Dis. 28: 169-79. PMID: 15877206
4. Rapid simulation and analysis of isotopomer distributions using constraints based on enzyme mechanisms: an example from HT29 cancer cells.  |  Selivanov, VA., et al. 2005. Bioinformatics. 21: 3558-64. PMID: 16002431
5. Transaldolase is part of a supramolecular complex containing glucose-6-phosphate dehydrogenase in human neutrophils that undergoes retrograde trafficking during pregnancy.  |  Huang, JB., et al. 2005. Metabolism. 54: 1027-33. PMID: 16092052
6. Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence.  |  Kleijn, RJ., et al. 2005. FEBS J. 272: 4970-82. PMID: 16176270
7. CD8+ T cell-mediated HLA-A*0201-restricted cytotoxicity to transaldolase peptide 168-176 in patients with multiple sclerosis.  |  Niland, B., et al. 2005. J Immunol. 175: 8365-78. PMID: 16339578
8. The pathogenesis of transaldolase deficiency.  |  Perl, A. 2007. IUBMB Life. 59: 365-73. PMID: 17613166
9. Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase.  |  Perl, A., et al. 2011. Trends Mol Med. 17: 395-403. PMID: 21376665
10. Transaldolase inhibits CD36 expression by modulating glutathione-p38 signaling, exerting protective effects against macrophage foam cell formation.  |  Li, C., et al. 2023. Acta Biochim Biophys Sin (Shanghai). 55: 1496-1505. PMID: 37528662
11. mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency.  |  Winans, T., et al. 2023. J Autoimmun. 140: 103112. PMID: 37742509
12. Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence.  |  Banki, K., et al. 1994. J Biol Chem. 269: 2847-51. PMID: 8300619

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Transaldolase Antibody (H-4) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Transaldolase Antibody (H-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Transaldolase Antibody (H-4) Specifications

Alternate Product Name: Transaldolase

Product Clone Name: H-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 24-60

Epitope Target: Transaldolase

Epitope Species: human

Product Reactivity/Detection: Transaldolase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Transaldolase Antibody (H-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin