TPX2 Antibody (B-10): sc-390183

TPX2 Antibody (B-10) is a mouse monoclonal IgG2b antibody that detects TPX2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TPX2, or targeting protein for Xklp2, is a crucial microtubule-associated protein that plays a significant role in microtubule assembly during cell division, particularly in the M phase of the cell cycle. TPX2 is essential for proper targeting of the motor protein Xklp2 to microtubules, facilitating chromatin-induced microtubule assembly. TPX2 function is vital as TPX2 ensures accurate spindle formation and chromosome segregation, which are critical for maintaining genomic stability. Additionally, TPX2 interacts with Aurora-A kinase at the spindle apparatus, where TPX2 may be regulated through phosphorylation, further emphasizing TPX2′s importance in the orchestration of mitotic processes. Disruption of TPX2 function, such as through RNA interference, leads to significant defects in microtubule organization during mitosis, highlighting TPX2′s indispensable role in cell division. With TPX2′s ability to activate Eg2 in a microtubule-dependent manner, TPX2 is integral to the regulation of mitotic spindle dynamics, making anti-TPX2 antibody (B-10) an invaluable tool for researchers studying cell cycle regulation and related pathways.

The preferred TPX2 antibody is TPX2 Antibody (E-2): sc-271570.