Date published: 2026-4-24

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TPX2 Inhibitors

TPX2 inhibitors belong to a class of chemical compounds specifically designed to target and modulate the activity or function of Targeting Protein for Xklp2 (TPX2). TPX2 is a protein that plays a crucial role in various cellular processes, particularly during cell division. It is involved in the regulation of the cell cycle and contributes to the assembly of the mitotic spindle, a structure critical for the accurate segregation of chromosomes during cell division. The mechanisms of action of TPX2 inhibitors may involve different approaches, depending on their specific targets within the TPX2-related pathways. Some inhibitors may directly interact with TPX2, hindering its ability to bind to other proteins or affect its cellular functions. Others might target upstream regulators or downstream effectors of TPX2, indirectly influencing its activity and cellular roles.

The study of TPX2 inhibitors has provided valuable insights into the molecular mechanisms underlying cell division and the importance of TPX2 in ensuring faithful chromosome segregation. By exploring TPX2 inhibitors, researchers aim to gain a better understanding of the complex regulatory networks governing cell division and its potential implications in cellular physiology. Continued research in this area may lead to further discoveries about TPX2-related biology, contributing to advancements in scientific knowledge and potential applications in diverse research fields.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

BI6727

755038-65-4sc-364432
sc-364432A
sc-364432B
sc-364432C
sc-364432D
5 mg
50 mg
100 mg
500 mg
1 g
$150.00
$1050.00
$1665.00
$3329.00
$4382.00
1
(1)

BI 6727 is a small molecule inhibitor of polo-like kinase 1 (PLK1), a protein kinase that phosphorylates TPX2 during cell division.

GSK 923295

1088965-37-0sc-490136
5 mg
$290.00
(0)

GSK923295 is an allosteric inhibitor of the TPX2 partner protein CENP-E kinesin motor. Inhibition of CENP-E interrupts the normal function of TPX2 during mitosis by preventing correct chromosome alignment and separation.

Hesperadin

422513-13-1sc-490384
10 mg
$304.00
(0)

Hesperadin is an inhibitor of Aurora B kinase, which is necessary for TPX2 function in spindle assembly and chromosome alignment. Without Aurora B activity, TPX2 cannot perform its mitotic functions efficiently.

ZM-447439

331771-20-1sc-200696
sc-200696A
1 mg
10 mg
$153.00
$356.00
15
(1)

ZM 447439 is an Aurora kinase inhibitor that reduces the functional activity of TPX2 by inhibiting its associated Aurora kinases.

Tozasertib

639089-54-6sc-358750
sc-358750A
25 mg
50 mg
$62.00
$87.00
4
(1)

Tozasertib is a multi-kinase inhibitor that targets Aurora A and B kinases, thus reducing the functional activity of TPX2.

Reversine

656820-32-5sc-203236
5 mg
$221.00
13
(1)

Reversine is a small molecule that inhibits the function of Aurora kinases A and B, thereby inhibiting the normal function of TPX2 in mitosis.