TPN Antibody (E-11): sc-393552

TPN Antibody (E-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects TPN protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TPN monoclonal antibody (E-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TPN protein, also known as tapasin, TPSN, TAPBP, or transporter associated with antigen processing-A, is a type I membrane glycoprotein encoded by a gene located on chromosome 6p21, producing a 488-residue protein. One of the critical aspects of TPN′s function is its role in the assembly and stabilization of major histocompatibility complex (MHC) class I molecules. TPN facilitates the loading of peptide antigens onto MHC class I molecules within the endoplasmic reticulum, a process essential for effective antigen presentation to CD8+ T cells. The cytoplasmic domain of TPN contains a double-lysine motif that is crucial for retention in the endoplasmic reticulum, ensuring that MHC class I molecules are properly loaded with peptides before being transported to the cell surface. Deficiencies in TPN lead to impaired MHC class I expression and reduced immune responses, highlighting TPN′s importance in the immune system′s ability to recognize and respond to intracellular pathogens.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TPN Antibody (E-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-TPN Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TPN Antibody (E-11) Specifications

Alternate Product Name: TPN

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 304-345

Epitope Target: TPN

Epitope Species: human

Product Reactivity/Detection: TPN

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for TPN Antibody (E-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred TPN antibody is TPN Antibody (TO-3): sc-80647.